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Pancreatic duct disruption with autosplenectomy

Hung-Hsu Hung1, Tseng-Shing Chen, Chien-Wei Su

  • 1Division of Gastroenterology, Department of Medicine, Taipei Veteran General Hospital and Faculty of Medicine, National Yang-Ming University, Taipei, Taiwan.

Gastroenterology
|November 3, 2009
PubMed
Summary

No abstract available in PubMed .

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The pathophysiology of acute pancreatitis centers on injury to pancreatic acinar cells, which initiates a cascade of harmful intracellular events.This injury leads to premature activation of trypsinogen to trypsin in the pancreas. Trypsin then activates other digestive enzymes, such as chymotrypsin, elastase, and phospholipase A2, which begin breaking down pancreatic tissue. The resulting autodigestion causes local inflammation, tissue swelling, hemorrhage, and fat necrosis.Injured acinar cells...

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