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Related Concept Videos

Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
Clinical Significance of Antibiotic Resistance01:25

Clinical Significance of Antibiotic Resistance

Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...
Proteomics01:33

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term proteomics...
Determinants of Bacterial Pathogenicity and Virulence01:20

Determinants of Bacterial Pathogenicity and Virulence

Pathogenic bacteria employ a variety of strategies to establish infections, including the secretion of extracellular enzymes that act as potent virulence factors. These enzymes facilitate bacterial colonization of host tissues and help evade immune surveillance. By targeting structural components of host tissues and interfering with immune mechanisms, these enzymes play a pivotal role in disease progression.Extracellular Enzymes Facilitating Tissue Invasion: Several bacterial pathogens secrete...
Mechanism of Antibiotic Resistance in MRSA01:25

Mechanism of Antibiotic Resistance in MRSA

Antibiotic resistance in bacteria arises when microorganisms evolve the ability to withstand drugs designed to kill them or inhibit their growth, rendering once-effective treatments useless. This phenomenon, driven by genetic change and selection under antibiotic exposure, poses a profound threat to modern medicine. Mechanisms include drug-inactivating enzymes (e.g., β-lactamases), efflux pumps that eject antibiotics, mutations altering antibiotic targets, decreased drug uptake, and acquisition...
Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
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Related Experiment Video

Updated: Jun 19, 2026

A Tandem Liquid Chromatography–Mass Spectrometry-based Approach for Metabolite Analysis of Staphylococcus aureus
08:03

A Tandem Liquid Chromatography–Mass Spectrometry-based Approach for Metabolite Analysis of Staphylococcus aureus

Published on: March 28, 2017

Proteomic approaches to study Staphylococcus aureus pathogenesis.

Patrice François1, Alexander Scherl, Denis Hochstrasser

  • 1Genomic Research Laboratory, Service of Infectious Diseases, Department of Internal Medicine, Geneva University and Geneva University Hospitals, 1211 Geneva 14, Switzerland.

Journal of Proteomics
|November 3, 2009
PubMed
Summary
This summary is machine-generated.

Staphylococcus aureus, a versatile pathogen, causes diverse infections. Proteomic studies enhance understanding of its virulence and adaptability, crucial for combating S. aureus infections.

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Quantifying the Cytotoxicity of Staphylococcus aureus Against Human Polymorphonuclear Leukocytes
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Quantifying the Cytotoxicity of Staphylococcus aureus Against Human Polymorphonuclear Leukocytes

Published on: January 3, 2020

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Last Updated: Jun 19, 2026

A Tandem Liquid Chromatography–Mass Spectrometry-based Approach for Metabolite Analysis of Staphylococcus aureus
08:03

A Tandem Liquid Chromatography–Mass Spectrometry-based Approach for Metabolite Analysis of Staphylococcus aureus

Published on: March 28, 2017

Quantifying the Cytotoxicity of Staphylococcus aureus Against Human Polymorphonuclear Leukocytes
12:27

Quantifying the Cytotoxicity of Staphylococcus aureus Against Human Polymorphonuclear Leukocytes

Published on: January 3, 2020

Area of Science:

  • Microbiology
  • Pathogen Research
  • Bacterial Pathogenesis

Background:

  • Staphylococcus aureus is a significant human and veterinary pathogen causing diverse infections.
  • Epidemiological shifts highlight its ubiquitous nature in hospital- and community-acquired infections, including methicillin-resistant strains.
  • Understanding S. aureus's adaptability and virulence factors is critical due to its global prevalence.

Purpose of the Study:

  • To review the impact of proteomic technologies on understanding Staphylococcus aureus virulence.
  • To elucidate the mechanisms behind S. aureus infection steps: colonization, virulence factor expression, invasion, and persistence.
  • To provide a comprehensive overview of bacterial metabolism, environmental adaptability, and pathogenicity.

Main Methods:

  • Analysis of whole genome sequences of pathogenic bacteria.
  • Application of advanced proteomic procedures to study S. aureus transcriptome and proteome.
  • Literature review summarizing proteomic insights into S. aureus virulence and pathogenesis.

Main Results:

  • Proteomic approaches offer a basis for understanding S. aureus metabolism and adaptability.
  • These methods facilitate detailed study of virulence factor expression and pathogenicity mechanisms.
  • The review consolidates current knowledge on proteomic contributions to S. aureus research.

Conclusions:

  • Proteomics has significantly advanced our comprehension of Staphylococcus aureus virulence.
  • Understanding bacterial adaptability and pathogenicity through proteomics is key to developing effective treatments.
  • Continued proteomic research is essential for addressing the challenges posed by S. aureus infections.