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Updated: Jun 19, 2026
05:17
Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
Published on: February 9, 2021
Synthesis and antitumor-evaluation of cyclopropyl-containing combretastatin analogs
Rita Fürst1, István Zupkó, Agnes Berényi
1Department of Organic Chemistry, University of Vienna, Währinger Strasse 38, 1090 Vienna, Austria.
Bioorganic & Medicinal Chemistry Letters
|November 3, 2009
Abstract:
Several derivatives of combretastatin have been prepared bearing a cyclopropyl unit instead of the natural occurring cis-double bond. Final products and synthetic intermediates were evaluated for their cytotoxic properties in two human cancer cell lines.
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