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Polycystin-1 and -2 dosage regulates pressure sensing

Reza Sharif-Naeini1, Joost H A Folgering, Delphine Bichet

  • 1Institut de Pharmacologie Moléculaire et Cellulaire, UMR CNRS 6097, Université de Nice Sophia Antipolis, 06560 Valbonne, France.

Cell
|November 3, 2009
PubMed
Summary

Polycystins TRPP1 and TRPP2 regulate cellular pressure sensing by modulating stretch-activated ion channels (SACs). The TRPP1/TRPP2 ratio and interaction with filamin A are critical for this mechanosensitivity.

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