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Induced Pluripotent Stem Cells

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...

Induced Pluripotent Stem Cells

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic cells are...

Induced Pluripotent Stem Cells

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...

EPS and iPS Cells in Disease Research

EPS and iPS Cells in Disease Research

Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...

iPS Cell Differentiation

iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.

Somatic to iPS Cell Reprogramming

Somatic to iPS Cell Reprogramming

Reprogramming alters the gene expression in somatic cells, transforming them into induced pluripotent stem (iPS) cells over several generations. Scientists can reprogram cells by introducing genes for four transcription factors—Oct4, Sox2, Klf4, and c-Myc (OSKM) by viral or non-viral methods. These factors are also known as Yamanaka factors after Shinya Yamanaka, who first generated iPS cells using mouse skin cells. Yamanaka was awarded the Nobel Prize in Physiology or Medicine in 2012 for this...

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Related Experiment Video

Updated: Jun 19, 2026

Efficient Generation Human Induced Pluripotent Stem Cells from Human Somatic Cells with Sendai-virus

Efficient Generation Human Induced Pluripotent Stem Cells from Human Somatic Cells with Sendai-virus

Published on: April 23, 2014

[Induced pluripotent stem cells (iPS cells)].

¹Université Claude-Bernard Lyon-I, 8, avenue Rockefeller, 69008 Lyon, France. daniel.germain@free.fr

Pathologie-Biologie

|November 3, 2009

Summary

This summary is machine-generated.

Induced pluripotent stem cells (iPS cells) offer an ethically sound alternative to embryonic stem cells for disease research and drug discovery. Ongoing research aims to improve iPS cell reprogramming for future therapeutic applications.

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Area of Science:

Stem cell biology
Cellular reprogramming
Regenerative medicine

Context:

Induced pluripotent stem cells (iPS cells) represent a significant advancement in stem cell technology.
They offer an ethically uncompromised alternative to embryonic stem cells.
The generation of iPS cells from adult somatic cells has emerged as a key technique.

Purpose:

To highlight the potential of human iPS cells in disease modeling and pharmacological research.
To underscore the importance of improving iPS cell reprogramming efficiency.
To discuss the future role of iPS cells in cellular therapy.

Summary:

Human iPS cells, derived from adult cells, provide an ethically sound and accessible source for studying diseases at the cellular level.
These cells are of significant interest to pharmacologists for drug development.
Active global research focuses on enhancing the quality of iPS cell reprogramming.

Impact:

iPS cells facilitate in-depth cellular-level studies of various disorders.
They offer a valuable material for pharmacological research and drug discovery.
The advancement of iPS cell technology holds promise for future human cellular therapies.