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Hypolipidemic effects of three purgative decoctions
Sung-Hui Tseng1, Ting-Yi Chien, Jiun-Rong Chen
1School of Medicine, Taipei Medical University, 250 Wu- Xing Street, Taipei 110, Taiwan.
Evidence-Based Complementary and Alternative Medicine : Ecam
|November 3, 2009
Summary
Traditional Chinese Medicine purgatives Xiao-Chen-Chi-Tang (XCCT) and Tiao-Wei-Chen-Chi-Tang (TWCCT) show promise for treating hyperlipidemia by lowering cholesterol and triglycerides without affecting body weight.
Area of Science:
- Integrative Medicine
- Pharmacology
- Traditional Chinese Medicine (TCM)
Background:
- TCM uses purgatives like Ta-Cheng-Chi-Tang (TCCT), Xiao-Chen-Chi-Tang (XCCT), and Tiao-Wei-Chen-Chi-Tang (TWCCT) for illnesses linked to internal heat accumulation.
- Obesity with specific symptoms is often treated with these purgatives, with rhubarb as a key ingredient.
- Previous research indicated TCCT's anti-inflammatory and XCCT's antioxidant properties.
Purpose of the Study:
- To review the literature on rhubarb's effects on lipid and weight control.
- To investigate the anti-obesity and lipid-lowering effects of TCCT, XCCT, TWCCT, and rhubarb extracts in animal models.
Main Methods:
- Literature review on rhubarb and its preparations for lipid and weight management.
- In vivo studies using two animal models to assess the effects of TCCT, XCCT, TWCCT, and rhubarb extracts.
- Evaluation of serum lipid concentrations, body weight, and renal/hepatic function.
Main Results:
- Tiao-Wei-Chen-Chi-Tang (TWCCT) demonstrated significant triglyceride reduction in mice, comparable to fenofibrate.
- Xiao-Chen-Chi-Tang (XCCT) and TWCCT attenuated high-fat diet-induced hypercholesterolemia in rats.
- TWCCT also reduced high-fat diet-induced hypertriglyceridemia in rats.
- No adverse effects on renal or hepatic function were observed.
- None of the tested extracts reduced body weight in high-fat diet-fed rats.
Conclusions:
- XCCT and TWCCT show potential therapeutic benefits for hyperlipidemia.
- These TCM formulations may help manage cholesterol and triglyceride levels.
- Further research is warranted to explore their clinical application in metabolic disorders.
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