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Related Experiment Video

Updated: Jun 19, 2026

Correction of Presbyopia by Monocular Bi-Aspheric Ablation Profile

Published on: September 20, 2024

Corneal higher-order aberrations in amblyopia.

Agata R Plech¹, David P Pinero, Carlos Laria

¹Vissum/Instituto Oftalmológico de Alicante, Universidad de Alicante, Alicante - Spain.

European Journal of Ophthalmology

|November 3, 2009

Summary

Lower order aberrations primarily cause amblyopia. Higher order aberrations may contribute to bilateral amblyopia, especially in isometropic cases, impacting visual acuity and corneal metrics.

Related Experiment Videos

Last Updated: Jun 19, 2026

Correction of Presbyopia by Monocular Bi-Aspheric Ablation Profile

Published on: September 20, 2024

Area of Science:

Ophthalmology
Optometry
Vision Science

Background:

Amblyopia, or

Purpose of the Study:

Investigate corneal higher order aberrations in adult amblyopia.
Differentiate between isotropic and anisometropic amblyopic patients.

Main Methods:

Corneal topographic and aberrometric analysis of 125 eyes.
Included unilateral amblyopia, bilateral amblyopia, and control groups.
Analyzed root mean square (RMS) parameters and ocular residual astigmatism (ORA).

Main Results:

Unilateral amblyopia showed significant differences in cylinder, BCVA, and RMS between eyes.
Bilateral amblyopia differed from controls in sphere, cylinder, and BCVA.
Isometropic bilateral amblyopia had higher total and astigmatic RMS compared to anisometropic.

Conclusions:

Lower order aberrations are primary drivers of amblyopia.
Higher order aberrations may play a bilateral amblyogenic role in isometropic amblyopia.