Related Experiment Video
Updated: Jun 19, 2026
04:56
Determination of the Procoagulant Activity of Extracellular Vesicle (EV) Using EV-Activated Clotting Time (EV-ACT)
Published on: August 4, 2023
[Hemostasis disorders in coal miners].
Meditsina Truda I Promyshlennaia Ekologiia
|November 3, 2009
Summary
Coal miners exposed to vibration and dust experience blood clotting issues, including increased platelet aggregation and hypercoagulation. These hemostasis disorders may accelerate coronary atherosclerosis development in affected workers.
Area of Science:
- Occupational Health
- Cardiovascular Science
- Hematology
Background:
- Occupational exposure to vibration and coal dust is prevalent in the mining industry.
- Vibration and dust exposure are potential risk factors for cardiovascular diseases.
- Understanding the impact on hemostasis is crucial for worker health.
Purpose of the Study:
- To investigate the effects of long-term exposure to vibration instruments and coal dust on hemostasis in coal miners.
- To identify specific hemostatic alterations associated with occupational exposures in this cohort.
- To explore the potential link between these hemostatic changes and the development of coronary atherosclerosis.
Main Methods:
- Assessing endothelial function in coal miners.
- Measuring platelet aggregation.
- Evaluating coagulation and anticoagulation activity.
- Correlating hemostatic parameters with occupational exposure history.
Main Results:
- Coal miners with prolonged exposure to vibration and coal dust exhibited endothelial dysfunction.
- Significant increases in platelet aggregation and hypercoagulation were observed.
- Anticoagulation activity was found to be reduced in the exposed workers.
- These hemostatic disorders were identified as potential contributors to early coronary atherosclerosis.
Conclusions:
- Long-term occupational exposure to vibration and coal dust induces significant hemostasis disorders in coal miners.
- The observed hemostatic alterations, including endothelial dysfunction and altered coagulation, may predispose miners to premature coronary atherosclerosis.
- Implementing preventative measures and health surveillance programs is recommended for this high-risk occupational group.
Related Concept Videos
01:24Disorders of Hemostasis
Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
01:30Venous Thrombosis IV: Nursing Management
Nursing management begins with a thorough assessment of the patient's health history. Key factors include trauma to veins, peripherally inserted central catheters, varicose veins, recent pregnancy or childbirth, surgery, bacteremia, prolonged bed rest, atrial fibrillation, COPD, heart failure, cancer, coagulation disorders, myocardial infarction, spinal cord injury, stroke, prolonged travel, recent bone fractures, and dehydration. Review medication intake, particularly oral contraceptives,...
01:19Pulmonary Embolism I: Introduction
A blood clot, or thrombus, is a semi-solid mass composed of fibrin, platelets, and red blood cells. When it forms within a vessel, it can obstruct blood flow, known as thrombosis. If part of the clot detaches, it becomes an embolus that can travel and block distant vessels. When this occurs in the pulmonary arteries, it causes a condition known as pulmonary embolism (PE).Origin and ImpactMost often, the embolus originates from a thrombus in the deep veins of the lower limbs, a condition called...
01:29Pulmonary Embolism I: Introduction
Pulmonary embolism (PE) occurs when a thrombus, fat or air embolus, amniotic fluid, or tumor tissue blocks one or more pulmonary arteries. These blockages originate in the venous system or the right side of the heart.EtiologyPE primarily arises from deep vein thrombosis (DVT) and other hypercoagulable states, such as inherited thrombophilias. Additional etiological factors include venous stasis, commonly seen in obesity, and endothelial injury from surgery and trauma. Less common causes include...
01:29Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care
Diagnosing Pulmonary EmbolismDiagnosing pulmonary embolism (PE) involves clinical assessment and advanced imaging tests. The preferred diagnostic tool is the spiral (helical) CT scan or CT angiography (CTA), which uses intravenous contrast media to visualize the pulmonary vasculature and identify emboli.A ventilation-perfusion (V/Q) scan is an alternative for patients unable to receive contrast media. This scan includes both perfusion and ventilation scanning. Perfusion scanning involves...
01:27Pulmonary Embolism III: Nursing Management
A pulmonary embolism occurs when a thrombus, amniotic fluid, tumor tissue, fat, or air embolus blocks one or more pulmonary arteries. Effective nursing management and patient education are crucial for improving outcomes and preventing recurrence.Nursing management starts with obtaining a comprehensive patient history, particularly noting any history of deep vein thrombosis (DVT). Assess for clinical manifestations, including dyspnea, chest pain, crackles, heart murmurs, and signs of right-sided...