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Updated: Jun 19, 2026

05:46
Rapid Screening of HIV Reverse Transcriptase and Integrase Inhibitors
Published on: April 9, 2014
[The antiretroviral agent Fullevir].
Voprosy Virusologii
|November 4, 2009
Summary
Fullevir demonstrates significant antiretroviral properties against the human immunodeficiency virus (HIV) in cell cultures. This promising drug effectively protects cells and shows synergistic effects with existing treatments.
Area of Science:
- Virology
- Pharmacology
Context:
- Human cell cultures infected with human immunodeficiency virus (HIV) were used to evaluate Fullevir's antiretroviral potential.
- Fullevir, a sodium salt of fullerenepolyhydropolyaminocaproic acid, was investigated for its efficacy.
Purpose:
- To assess the antiretroviral properties of Fullevir against HIV.
- To determine Fullevir's effective concentration (EF90) and toxic concentration (TC50).
- To evaluate different dosage regimens and combination therapies involving Fullevir.
Summary:
- Fullevir demonstrated significant protection against HIV-induced cytopathic effects with an EF90 of 5 microg/ml and a TC50 of 400 microg/ml.
- The drug proved effective in preventive, therapeutic, and simultaneous administration, with longer contact enhancing antiviral defense.
- Co-administration with Retrovir (azidothymidine) resulted in a synergistic antiretroviral effect.
Impact:
- Fullevir shows promise as a novel antiretroviral agent for HIV treatment.
- The findings suggest Fullevir could be a valuable addition to HIV therapy, potentially enhancing existing treatment regimens.
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