Related Experiment Video
Updated: Jun 19, 2026
08:03
Midface Hypoplasia and Cranial Base Morphology in Syndromic Craniosynostosis: A Comparative Analysis Study Using a Predictive Regression Model
Published on: November 4, 2025
Syndromes and anomalies associated with cleft
1Department of Plastic Surgery, Sri Ramachandra University, Chennai, India.
Summary
Orofacial clefts, common birth defects, frequently occur with other congenital anomalies. This study analyzes associated anomalies in syndromic and nonsyndromic cleft cases from an Indian tertiary center.
Area of Science:
- Medical Genetics
- Pediatric Surgery
- Public Health
Background:
- Orofacial clefts represent a significant global birth defect prevalence.
- While often isolated, orofacial clefts can present with syndromic or nonsyndromic classifications, frequently accompanied by other congenital anomalies.
Purpose of the Study:
- To investigate the spectrum and frequency of associated anomalies in patients with orofacial clefts.
- To analyze data from a tertiary cleft center in India to understand local patterns of syndromic and nonsyndromic clefts with anomalies.
Main Methods:
- Literature review of existing studies on orofacial clefts and associated anomalies.
- Retrospective analysis of patient data from a tertiary cleft care center in India.
Main Results:
- A substantial proportion of orofacial cleft cases, irrespective of syndromic or nonsyndromic status, exhibit associated congenital anomalies.
- The study provides specific data on the types and prevalence of anomalies observed in the Indian cohort.
Conclusions:
- Associated anomalies are a critical consideration in the management of orofacial clefts.
- Understanding these associations is vital for comprehensive patient care and genetic counseling, particularly within diverse populations like India.
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