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Related Experiment Video

Updated: Jun 19, 2026

Targeted and Selective Treatment of Pluripotent Stem Cell-derived Teratomas Using External Beam Radiation in a Small-animal Model

Targeted and Selective Treatment of Pluripotent Stem Cell-derived Teratomas Using External Beam Radiation in a Small-animal Model

Published on: February 17, 2019

Radiation-induced spindle cell sarcoma: a rare case report.

Mubeen Khan¹, Rupa Chandramala, Ridhima Sharma

¹Department of Oral Medicine and Radiology, Government Dental College and Research Institute, Bangalore, India.

Indian Journal of Dental Research : Official Publication of Indian Society for Dental Research

|November 4, 2009

Summary

Radiation therapy can rarely cause secondary spindle cell sarcomas, even years later. This case highlights a rare sarcoma developing in the maxilla after childhood retinoblastoma treatment.

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Last Updated: Jun 19, 2026

Targeted and Selective Treatment of Pluripotent Stem Cell-derived Teratomas Using External Beam Radiation in a Small-animal Model

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Tumorsphere Derivation and Treatment from Primary Tumor Cells Isolated from Mouse Rhabdomyosarcomas

Tumorsphere Derivation and Treatment from Primary Tumor Cells Isolated from Mouse Rhabdomyosarcomas

Published on: September 13, 2019

Area of Science:

Oncology
Radiation Oncology
Pathology

Background:

Ionizing radiation is a known carcinogen, with radiation-induced sarcomas being a recognized late complication of radiotherapy.
Most radiation-induced sarcomas occur after high cumulative doses (≥55 Gray), but the latency period and specific subtypes remain areas of interest.

Observation:

A rare case of spindle cell sarcoma of the left maxilla is reported in a 24-year-old male.
The patient had previously received Cobalt-60 radiotherapy for left eye retinoblastoma 21 years prior to sarcoma development.

Findings:

This represents an exceptionally uncommon instance of spindle cell sarcoma arising in the head and neck region following radiotherapy.
The latency period of 21 years is notable, underscoring the potential for very late-onset radiation-induced malignancies.

Implications:

This case contributes to the understanding of rare oncological outcomes following pediatric cancer treatment.
It emphasizes the importance of long-term surveillance for patients treated with radiotherapy, particularly for head and neck sarcomas.
Further research into the specific mechanisms and risk factors for developing sarcomas after radiotherapy is warranted.