Microbial transformation of a monoterpene, geraniol, by the marine-derived fungus Hypocrea sp
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Updated: Jun 19, 2026

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Alain S Leutou1, Guohua Yang, Viviane N Nenkep
1Department of Chemistry, Pukyong National University, Busan 608-737, Korea.
Abstract:
Geraniol (1) is the biogenetic precursor of a number of monoterpenes. We tested various marine-derived microorganisms to determine their ability to biotransform 1. Only Hypocrea sp. was capable of transforming 1 into its oxidized derivative, 1,7-dihydroxy-3,7-dimethyl-(E)-oct- 2-ene (2). The structure of the metabolite obtained was assigned on the basis of detailed spectroscopic data analyses.
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