Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Systemic local anesthetics in pain control.

S Glazer, R K Portenoy

    Journal of Pain and Symptom Management
    |January 1, 1991
    PubMed
    Summary

    Systemic local anesthetics offer pain relief, particularly for neuropathic pain syndromes. Recent oral formulations and studies support their use as effective analgesics in specific conditions.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Improvements in Survival and Clinical Benefit With Gemcitabine as First-Line Therapy for Patients With Advanced Pancreas Cancer: A Randomized Trial.

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology·2023
    Same author

    Motor Effects of Minimal Traumatic Brain Injury in Mice.

    Journal of molecular neuroscience : MN·2019
    Same author

    A phase I clinical trial demonstrates that nfP2X<sub>7</sub> -targeted antibodies provide a novel, safe and tolerable topical therapy for basal cell carcinoma.

    The British journal of dermatology·2017
    Same author

    Pharmacotherapy of Cancer PainA Practical Guide.

    Journal of back and musculoskeletal rehabilitation·2014
    Same author

    Evaluation of back pain caused by epidural neoplasm.

    Journal of back and musculoskeletal rehabilitation·2014
    Same author

    Antidote strategies to reverse anticoagulation with TB-402, a long-acting partial inhibitor of factor VIII.

    Journal of thrombosis and haemostasis : JTH·2012

    Area of Science:

    • Pharmacology
    • Pain Management
    • Neurology

    Background:

    • Local anesthetics have demonstrated analgesic properties for over 40 years.
    • Recent advancements include oral formulations, increasing interest in their therapeutic potential.
    • Controlled studies suggest efficacy in managing neuropathic pain syndromes.

    Purpose of the Study:

    • To review the pharmacology of local anesthetics.
    • To critically evaluate existing medical literature on systemic local anesthetic administration for analgesia.
    • To assess the evidence supporting the use of local anesthetics as analgesics.

    Main Methods:

    • Literature review of pharmacology.
    • Critical evaluation of controlled studies.
    • Analysis of medical literature on systemic administration for pain relief.

    Main Results:

    • The data support the analgesic effect of systemically administered local anesthetics.
    • Efficacy is noted in specific pain syndromes, especially neuropathic pain.
    • Oral formulations have enhanced interest and research in this area.

    Conclusions:

    • Systemic local anesthetics are effective analgesics in selected pain conditions.
    • Further research and clinical application are warranted, particularly with new formulations.
    • Local anesthetics represent a viable option for managing certain types of chronic pain.

    Related Experiment Videos