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Updated: Jun 19, 2026

Investigations on the Ga(III) Complex of EOB-DTPA and Its 68Ga Radiolabeled Analogue
Published on: August 17, 2016
A new bifunctional Gd(III) complex of enhanced efficacy for MR-molecular imaging applications
Lorenzo Tei1, Giuseppe Gugliotta, Zsolt Baranyai
1Dipartimento di Scienze dell'Ambiente e della Vita, Università del Piemonte Orientale Amedeo Avogadro, Viale T. Michel 11, I-15121, Alessandria, Italy.
Abstract:
Increasing the length of the carboxyamide arm of a GdDOTA monoamide (DOTA = 1,4,7,10-tetraaza-1,4,7,10-tetrakis(carboxymethyl)cyclododecane) complex from acetic to propionic accelerates the water exchange rate (k(ex)) by nearly two orders of magnitude; the (1)H relaxivity of the corresponding macromolecular derivatives may then be remarkably enhanced in MRI-based molecular imaging applications, as exemplified in the case of micellar systems.

