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The lower urinary system consists of the urinary bladder and urethra, which are essential in storing and expelling urine from the body. Together with the internal and external sphincters, these structures work together to regulate urination effectively.Anatomy of the BladderThe urinary bladder is a muscular, stretchable organ behind the pubic bone and in front of the rectum. In females, the bladder is positioned anterior to the vagina and inferior to the uterus, while in males, it is located...

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Related Experiment Video

Updated: Jun 19, 2026

Evaluation of Biomaterials for Bladder Augmentation using Cystometric Analyses in Various Rodent Models

Evaluation of Biomaterials for Bladder Augmentation using Cystometric Analyses in Various Rodent Models

Published on: August 9, 2012

Urinary bladder auto augmentation using INTEGRA and SURGISIS: an experimental model.

Gera Parshotam Kumar¹, Andrew Barker, Saeed Ahmed

¹Princess Margaret Hospital for Children, Perth, Australia. gerapk@rediffmail.com

Pediatric Surgery International

|November 4, 2009

Summary

The collagen layer of INTEGRA demonstrated superior urinary bladder auto augmentation compared to SURGISIS and enterocystoplasty in a lamb model, showing improved compliance and elasticity.

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Evaluation of Biomaterials for Bladder Augmentation using Cystometric Analyses in Various Rodent Models

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Area of Science:

Regenerative Medicine
Biomaterials Science
Urology

Background:

Urinary bladder augmentation is crucial for managing conditions causing bladder dysfunction.
Current augmentation methods, like enterocystoplasty, have limitations.
Novel biomaterials offer potential for improved bladder reconstruction.

Purpose of the Study:

To evaluate the efficacy of SURGISIS and INTEGRA (collagen layer) for urinary bladder auto augmentation.
To compare the functional and histological outcomes of these biomaterials against seromuscular enterocystoplasty.
To assess changes in bladder compliance and elasticity.

Main Methods:

An experimental urinary bladder auto augmentation model was established in 18 lambs.
Three groups were formed: seromuscular enterocystoplasty, SURGISIS, and INTEGRA (collagen layer).
Bladder compliance, elasticity, and histological features were assessed after 3 months.

Main Results:

The INTEGRA group exhibited significantly improved bladder compliance compared to controls.
Histological examination revealed neovascularization in SURGISIS and INTEGRA groups.
The INTEGRA group demonstrated superior elastic properties and fewer adverse events than SURGISIS and enterocystoplasty.

Conclusions:

The collagen layer of INTEGRA represents a promising biomaterial for urinary bladder auto augmentation.
INTEGRA offers better functional and histological outcomes than SURGISIS and demucosalized enterocystoplasty in this model.
Further research is warranted to translate these findings to clinical practice.