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Updated: Jun 19, 2026

Isolation of Human Islets from Partially Pancreatectomized Patients

Isolation of Human Islets from Partially Pancreatectomized Patients

Published on: July 30, 2011

Thyroid function and insulin sensitivity before and after bilio-pancreatic diversion.

Donatella Gniuli¹, Laura Leccesi, Caterina Guidone

¹Department of Internal Medicine and Diabetes Center, Catholic University, L.go Gemelli 8, 00168 Rome, Italy. dgniuli@gmail.com

Obesity Surgery

|November 4, 2009

Summary

Bilio-pancreatic diversion surgery increases hypothyroidism risk in obese patients. Post-surgery, more patients developed subclinical or frank hypothyroidism, especially those with prior thyroid issues.

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Last Updated: Jun 19, 2026

Isolation of Human Islets from Partially Pancreatectomized Patients

Isolation of Human Islets from Partially Pancreatectomized Patients

Published on: July 30, 2011

Area of Science:

Endocrinology
Bariatric Surgery
Metabolic Disorders

Background:

Bilio-pancreatic diversion (BPD) is a bariatric surgery causing significant weight loss via malabsorption.
BPD alters entero-hepatic circulation, potentially impacting thyroid hormone metabolism.
The study investigates thyroid hormone changes following BPD in obese patients.

Purpose of the Study:

To evaluate modifications in circulating thyroid hormones after BPD.
To assess the prevalence of hypothyroidism before and after BPD.
To identify factors contributing to thyroid dysfunction post-BPD.

Main Methods:

Forty-five obese patients were studied pre- and 2-years post-BPD.
Assessed thyroid-stimulating hormone (TSH), free triiodothyronine (fT3), free thyroxine (fT4), and anti-thyroid antibodies.
Included lipid profile, glucose/insulin levels, HOMA IR index, and neck ultrasonography.

Main Results:

Pre-BPD, 23% had subclinical hypothyroidism; post-BPD, this rose to 40.42%.
6.3% developed frank hypothyroidism post-BPD, without autoimmune thyroiditis.
Patients developing hypothyroidism post-BPD often had pre-existing thyroid alterations (goiter, cysts).

Conclusions:

BPD increases the prevalence of subclinical and frank hypothyroidism.
Mechanisms include iodine malabsorption and fT3 loss due to altered entero-hepatic circulation.
Iodine supplementation and careful thyroid hormone monitoring/therapy are recommended, especially for patients with pre-existing thyroid conditions.