Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hormonal Regulation of Blood Pressure01:17

Hormonal Regulation of Blood Pressure

Endocrinal or hormonal intervention in the cardiovascular system is predominantly exerted by the catecholamines - epinephrine and norepinephrine, as well as a slew of hormones that interact with renal function to modulate blood volume.
Epinephrine and Norepinephrine
The adrenal medulla releases epinephrine and norepinephrine, catecholamines that enhance and extend the sympathetic or "fight or flight" physiological response. These hormones escalate heart rate and the force of contraction while...
Physiology of the Genitourinary System III: Urine Concentration and Dilution01:20

Physiology of the Genitourinary System III: Urine Concentration and Dilution

The kidneys concentrate or dilute urine to maintain water and electrolyte balance. Nephrons, particularly the loop of Henle, play a crucial role in this process through the countercurrent multiplication system. This system establishes a high osmolarity in the renal medulla, which is essential for water reabsorption. In the loop of Henle’s descending limb, water is reabsorbed into the surrounding medulla due to its permeability to water. In contrast, the ascending limb actively transports...
Extracorporeal Removal of Drugs: Hemoperfusion and Hemofiltration01:25

Extracorporeal Removal of Drugs: Hemoperfusion and Hemofiltration

Hemoperfusion and hemofiltration are critical techniques in medical treatments to eliminate accumulated drugs, metabolites, and electrolytes from the bloodstream. These methods are particularly vital in cases of accidental poisoning and drug overdose.Hemoperfusion involves passing blood through an adsorbent material to remove unwanted substances. The main adsorbents used in hemoperfusion include activated charcoal and Amberlite resins. Activated charcoal can adsorb both polar and nonpolar...
Hemodialysis II: Procedure and Complications01:24

Hemodialysis II: Procedure and Complications

DialyzersA hemodialysis (HD) dialyzer is a plastic cartridge containing thousands of parallel hollow fibers, which serve as semipermeable membranes. These fibers are typically made from cellulose-based or other synthetic materials. During HD, blood is pumped into the top of the cartridge and distributed among these fibers. Simultaneously, dialysis fluid, known as dialysate, is introduced into the bottom of the cartridge, bathing the outside of the fibers. Across the semipermeable membrane,...
Antihypertensive Drugs: Action of Diuretics01:16

Antihypertensive Drugs: Action of Diuretics

Diuretics are antihypertensive drugs used to treat hypertension resulting from sodium and water retention. Sodium, vital for fluid balance and nerve or muscle function, is regulated by the kidneys through millions of nephrons. Blood enters nephrons via afferent arterioles, which branch into capillaries called glomeruli. These filter blood plasma, allowing water and solutes, like sodium ions, to pass through capillary walls into Bowman's capsule. The filtrate then flows through various tubules...
Heart Failure Drugs: Diuretics01:22

Heart Failure Drugs: Diuretics

Heart failure and kidney perfusion are interconnected in a complex way. Reduced renal perfusion and venous congestion are two significant factors that contribute to renal dysfunction in heart failure. The kidneys, primarily responsible for fluid balance in the body, are adversely affected due to compromised cardiac output and increased venous pressure. In response to reduced renal perfusion, the kidneys activate neurohumoral mechanisms to restore balance. However, these mechanisms can be...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Translated article] Pilot study to determine the association between gut microbiota and fragility hip fracture.

Revista espanola de cirugia ortopedica y traumatologia·2023
Same author

Negative preoperative RT-PCR screening is no guaranty of no SARS-CoV-2 infection.

Revista espanola de anestesiologia y reanimacion·2023
Same author

Pilot study to determine the association between gut microbiota and fragility hip fracture.

Revista espanola de cirugia ortopedica y traumatologia·2023
Same author

Study of the fatigue delamination behaviour of adhesive joints in carbon fibre reinforced epoxy composites, influence of the period of exposure to saline environment.

Scientific reports·2022
Same author

Reversal of age-associated frailty by controlled physical exercise: The pre-clinical and clinical evidences.

Sports medicine and health science·2022
Same author

Estrogen Replacement Therapy Induces Antioxidant and Longevity-Related Genes in Women after Medically Induced Menopause.

Oxidative medicine and cellular longevity·2021

Related Experiment Video

Updated: Jun 19, 2026

Continuous Venous-Arterial Doppler Ultrasound During a Preload Challenge
09:32

Continuous Venous-Arterial Doppler Ultrasound During a Preload Challenge

Published on: January 20, 2023

Desmopresssin and hemodilution: implications in doping.

F Sanchis-Gomar1, V E Martinez-Bello, A L Nascimento

  • 1Faculty of Medicine, Department of Phisiology, University of Valencia, Valencia, Spain.

International Journal of Sports Medicine
|November 4, 2009
PubMed
Summary
This summary is machine-generated.

Desmopressin (DDAVP) effectively dilutes blood, significantly lowering hematological markers like hematocrit and hemoglobin. This study suggests DDAVP could be misused in sports to mask blood doping, warranting its inclusion on the WADA prohibited list.

More Related Videos

Invasive Hemodynamic Monitoring of Aortic and Pulmonary Artery Hemodynamics in a Large Animal Model of ARDS
08:12

Invasive Hemodynamic Monitoring of Aortic and Pulmonary Artery Hemodynamics in a Large Animal Model of ARDS

Published on: November 26, 2018

Related Experiment Videos

Last Updated: Jun 19, 2026

Continuous Venous-Arterial Doppler Ultrasound During a Preload Challenge
09:32

Continuous Venous-Arterial Doppler Ultrasound During a Preload Challenge

Published on: January 20, 2023

Invasive Hemodynamic Monitoring of Aortic and Pulmonary Artery Hemodynamics in a Large Animal Model of ARDS
08:12

Invasive Hemodynamic Monitoring of Aortic and Pulmonary Artery Hemodynamics in a Large Animal Model of ARDS

Published on: November 26, 2018

Area of Science:

  • Sports Science
  • Anti-doping Research
  • Pharmacology

Background:

  • Blood doping is a performance-enhancing practice in sports.
  • Anti-doping agencies use hematological parameters to detect illegal blood manipulation.
  • Plasma volume expanders are prohibited substances used to artificially alter these values.

Purpose of the Study:

  • To investigate the hemodilution effects of desmopressin (DDAVP).
  • To determine if DDAVP-induced hemodilution can alter key hematological parameters used in blood doping detection.
  • To assess the potential for DDAVP misuse in sports doping.

Main Methods:

  • An intra-subject crossover study involving eight physically active males.
  • Administration of 1.5 L mineral water with 4.3 microg/kg DDAVP on one occasion.
  • Administration of 1.5 L mineral water alone on a separate occasion.
  • Analysis of blood samples for hematocrit, hemoglobin, reticulocytes, OFF Hr-Score, glucose, albumin, creatinine, and total proteins.

Main Results:

  • DDAVP treatment significantly decreased hematocrit, hemoglobin, and OFF Hr-Score values.
  • Significant reductions in glucose, albumin, creatinine, and total proteins were observed, falling below physiological levels.
  • DDAVP demonstrated a potent hemodilution effect.

Conclusions:

  • Desmopressin (DDAVP) effectively induces hemodilution.
  • The observed changes in hematological parameters could potentially mask blood doping.
  • It is recommended that desmopressin (DDAVP) be added to the World Anti-Doping Agency (WADA) prohibited list.