Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mechanical Ventilation I: Indication and Settings01:29

Mechanical Ventilation I: Indication and Settings

Mechanical ventilation is a life-saving technique for managing acute respiratory failure and other respiratory complications. The process involves using a machine known as a ventilator to supply oxygen to the lungs and assist in removing carbon dioxide. It serves as a bridge to long-term mechanical ventilation or a temporary measure until ventilatory support is discontinued. The ventilator can maintain this function for a prolonged period, providing critical support for patients until they can...
Mechanical Ventilation II: Invasive Ventilation01:23

Mechanical Ventilation II: Invasive Ventilation

Ventilators are essential medical equipment used to aid patients with respiratory difficulties. Their primary function is to assist or replace spontaneous breathing by providing mechanical ventilation. There are two general classes of mechanical ventilators: negative-pressure and positive-pressure ventilators.
Negative-Pressure Ventilators
Negative-pressure ventilators create a vacuum around the chest or body to draw air into the lungs, simulating breathing. This method does not require an...
Mechanical Ventilation III: Noninvasive Ventilation01:23

Mechanical Ventilation III: Noninvasive Ventilation

Noninvasive positive-pressure ventilation (NIPPV), continuous positive airway pressure (CPAP), and bilevel positive airway pressure (BiPAP) are essential methods in respiratory care. These ventilation techniques offer unique benefits for patients with various respiratory conditions, providing adequate support without requiring intubation. Let's explore how each method is crucial in improving patient outcomes and enhancing respiratory therapy.
Noninvasive Positive-Pressure Ventilation (NIPPV)
Ventilatory Modes01:14

Ventilatory Modes

Mechanical ventilators are life-saving devices that support or replace spontaneous breathing. They deliver breaths to patients through varying methods known as ventilator modes. Understanding these modes is critical for healthcare providers managing patients with respiratory failure.
There are three ventilatory modes: full support, partial support, and spontaneous. These are described below.
Full Support Modes
Full support modes include controlled mechanical ventilation, continuous mandatory...
Factors Affecting Pulmonary Ventilation01:19

Factors Affecting Pulmonary Ventilation

Besides the pressure difference between the external environment and the lungs, the airflow rate and ease of pulmonary ventilation are also influenced by three other factors: surface tension of the fluid in the alveoli, compliance of the lungs, and airway resistance.
Alveolar Surface Tension
The alveolar fluid lines the luminal surface of the alveoli and exerts a force called surface tension. This force is caused by the polar water molecules in the liquid being more strongly attracted to each...
Acute Respiratory Failure-III01:30

Acute Respiratory Failure-III

Hypercapnic respiratory failure, also known as Type 2 or ventilatory respiratory failure, is a severe condition characterized by the body's inability to effectively remove carbon dioxide (CO2) from the bloodstream. It leads to an arterial CO2 pressure (PaCO2) exceeding 45 mmHg and a blood pH above 7.35. This situation indicates that the body's ventilatory demand, or the ventilation needed to maintain normal PaCO2 levels, surpasses its supply or the maximum gas flow achievable without causing...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Per- and polyfluoroalkyl substances (PFAS) in early life is associated with childhood intestinal inflammation: analyses of three birth cohorts.

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association·2026
Same author

Fetal exposure to persistent organic pollutants and childhood autism risk.

Environmental research·2026
Same author

"Impact of an Innovative Community-Academic Partnership Connecting Families Facing Food Insecurity with a Food Pantry".

Academic pediatrics·2026
Same author

Wqsreg: a Stata command for weighted quantile sum regression.

European journal of epidemiology·2026
Same author

Impact of Fostamatinib on Inflammatory Biomarkers in Hospitalized Patients With COVID-19.

Critical care explorations·2026
Same author

Prevalent detection of multiclass environmental chemicals in paired CSF and plasma samples and their potential associations with postpartum depressive symptoms in pregnant women.

Environmental research·2026

Related Experiment Video

Updated: Jun 19, 2026

A Structured Approach to Extubation in Mechanically Ventilated Rats
05:05

A Structured Approach to Extubation in Mechanically Ventilated Rats

Published on: July 18, 2025

Ineffective triggering predicts increased duration of mechanical ventilation.

Marjolein de Wit1, Kristin B Miller, David A Green

  • 1Division of Pulmonary Disease and Critical Care Medicine, Virginia Commonwealth University, Richmond, VA, USA. mdewit@mcvh-vcu.edu

Critical Care Medicine
|November 4, 2009
PubMed
Summary

High rates of ineffective triggering in mechanical ventilation (MV) are linked to longer ventilator use and reduced ventilator-free survival (VFS). This early MV complication increases patient morbidity and hospital stay.

More Related Videos

3D Cine Magnetic Resonance Imaging of Respiratory Motion in Mechanically Ventilated Mice and Rats
08:22

3D Cine Magnetic Resonance Imaging of Respiratory Motion in Mechanically Ventilated Mice and Rats

Published on: September 19, 2025

Related Experiment Videos

Last Updated: Jun 19, 2026

A Structured Approach to Extubation in Mechanically Ventilated Rats
05:05

A Structured Approach to Extubation in Mechanically Ventilated Rats

Published on: July 18, 2025

3D Cine Magnetic Resonance Imaging of Respiratory Motion in Mechanically Ventilated Mice and Rats
08:22

3D Cine Magnetic Resonance Imaging of Respiratory Motion in Mechanically Ventilated Mice and Rats

Published on: September 19, 2025

Area of Science:

  • Critical Care Medicine
  • Respiratory Physiology
  • Mechanical Ventilation

Background:

  • Ineffective triggering during mechanical ventilation (MV) is a frequent issue.
  • Early identification of factors influencing MV duration is crucial for patient outcomes.

Purpose of the Study:

  • To investigate the association between high rates of ineffective triggering within 24 hours of MV initiation and subsequent MV duration and ventilator-free survival (VFS).

Main Methods:

  • A prospective cohort study was conducted in a medical intensive care unit (ICU).
  • Sixty patients requiring invasive MV had their respiratory waveforms analyzed within the first 24 hours.
  • The ineffective triggering index (ITI) was calculated, and patients were categorized into ITI ≥10% or ITI <10% groups.

Main Results:

  • Sixteen out of 60 patients exhibited an ITI ≥10%.
  • Patients with ITI ≥10% experienced significantly longer MV duration (10 vs. 4 days) and shorter VFS (14 vs. 21 days).
  • This group also had longer ICU and hospital lengths of stay and a lower likelihood of discharge home.

Conclusions:

  • Ineffective triggering is a common early complication of mechanical ventilation.
  • High ITI is an independent predictor of increased morbidity, including prolonged MV, reduced VFS, and extended hospital stays.
  • Addressing ineffective triggering may improve patient outcomes in mechanically ventilated patients.