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Sensitivity of technetium-99m-d,1-HMPAO to radiolysis in aqueous solutions

K Tubergen¹, M Corlija, W A Volkert

¹Research Service, Harry S. Truman Veterans Administration Hospital, Columbia, Missouri.

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine

|January 1, 1991

Abstract:

The sensitivity of technetium-99m- (99mTc) d,l-HMPAO to radiolytically induced dissociation in aqueous solutions was investigated. It was found that cobalt-60 (60Co) gamma irradiation of solutions containing 99mTc-d,l-HMPAO with only 1600 cGy reduced the lipophilic chelates' radiochemical purity (RCP) to 50%-60%. The radiolytic sensitivity of 99mTc-meso-HMPAO is significantly lower. The results indicate that radiolytically produced intermediates limit the in vitro stability of 99mTc-d,l-HMPAO.

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