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Homocysteine and cerebrovascular accidents

Saikat Datta1, Salil K Pal, Hirak Mazumdar

  • 1Department of Medicine, NRS Medical College, Kolkata 700014.

Journal of the Indian Medical Association
|November 6, 2009
PubMed

Insights

Elevated homocysteine levels are linked to ischemic stroke but not hemorrhagic stroke. This study investigated homocysteine

Area of Science:

  • Neurology
  • Cardiovascular Medicine
  • Biochemistry

Background:

  • Hyperhomocysteinemia is a recognized risk factor for coronary artery disease, potentially accelerating atherosclerosis.
  • The role of hyperhomocysteinemia in cerebrovascular accidents (CVA) remains debated due to conflicting study results.

Purpose of the Study:

  • To correlate plasma homocysteine levels with ischemic and hemorrhagic CVA.
  • To assess the association between homocysteine and different CVA subtypes.

Main Methods:

  • Prospective study design.
  • Inclusion of 42 randomly selected CVA cases over one year.
  • Assessment of patient risk factors and measurement of serum homocysteine levels.

Main Results:

  • Significantly higher serum homocysteine levels were observed in patients with intracerebral infarcts (ischemic CVA) compared to those with intracerebral hemorrhage.
  • Homocysteine levels did not demonstrate prognostic significance for CVA outcomes in this cohort.

Conclusions:

  • Plasma homocysteine levels are elevated in ischemic CVA but not in hemorrhagic CVA.
  • Homocysteine may play a role in the pathogenesis of ischemic stroke.
  • Further research is needed to clarify the prognostic value of homocysteine in CVA.

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