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Related Experiment Video

Updated: Jun 19, 2026

Cutaneous Leishmaniasis in the Dorsal Skin of Hamsters: a Useful Model for the Screening of Antileishmanial Drugs

Cutaneous Leishmaniasis in the Dorsal Skin of Hamsters: a Useful Model for the Screening of Antileishmanial Drugs

Published on: April 21, 2012

Diffuse (anergic) cutaneous leishmaniasis responding to amphotericin B.

B Morrison¹, I Mendoza, D Delgado

¹New York University School of Medicine, New York, NY, USA.

Clinical and Experimental Dermatology

|November 6, 2009

Summary

Diffuse cutaneous leishmaniasis (DCL) is a rare, disfiguring skin disease. Amphotericin B effectively treated a severe DCL case, offering new therapeutic insights for this challenging zoonotic disease.

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Published on: December 30, 2012

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Cutaneous Leishmaniasis in the Dorsal Skin of Hamsters: a Useful Model for the Screening of Antileishmanial Drugs

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A Parasite Rescue and Transformation Assay for Antileishmanial Screening Against Intracellular Leishmania donovani Amastigotes in THP1 Human Acute Monocytic Leukemia Cell Line

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Published on: December 30, 2012

Area of Science:

Infectious Diseases
Parasitology
Dermatology
Immunology

Background:

American cutaneous leishmaniasis is an endemic zoonotic disease in the New World.
Diffuse cutaneous leishmaniasis (DCL) is a rare, severe manifestation characterized by antigen-specific immunodeficiency.
DCL presents with widespread, non-ulcerated nodules and plaques, clinically resembling lepromatous leprosy.

Observation:

Patients with advanced DCL often experience relapses despite aggressive chemotherapy.
Previous therapeutic strategies for DCL have yielded limited and inconsistent results.
A severe, exceptional case of DCL was observed.

Findings:

The severe DCL case reported demonstrated complete resolution following treatment with amphotericin B.
Amphotericin B, previously considered only mildly effective for DCL, proved successful in this exceptional case.
This case highlights the potential efficacy of amphotericin B in managing severe DCL.

Implications:

The findings suggest amphotericin B may be a viable therapeutic option for severe or refractory DCL.
Further investigation into the role of amphotericin B in DCL treatment is warranted.
This case contributes valuable information to the therapeutic approach for American cutaneous leishmaniasis.