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Intrafemoral Injection of Human Hematopoietic Stem and Progenitor Cells into Immunocompromised Mice
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[Mobilisation of haematopoietic stem cells with plerixafor--secondary publication]

Per Boye Hansen1, Eva Gaarsdal

  • 1Medicinsk Haematologisk Afdeling L, Herlev Hospital, DK-2730 Herlev, Denmark. peboha@heh.regionh.dk

Ugeskrift for Laeger
|November 6, 2009
PubMed

Plerixafor (AMD3100) is a selective antagonist of a receptor expressed on haematopoietic stem cells. This receptor normally binds to a ligand on bone marrow stromal cells, responsible for the homing and keeping the stem cells in place. Plerixafor has been successfully used in clinical trails in patients with malignant lymphoma and multiple myeloma, where mobilization of stem cells with granulocyte colony-stimulating factor for leukapheresis and later stem cell transplantation were not possible. Plerixafor has also been given with success to healthy donors for harvest and haematopoietic allograft.

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