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Related Concept Videos

Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...
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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
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Regulation of Hematopoietic Stem Cells01:01

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All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
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The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
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The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...

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Related Experiment Video

Updated: Jun 19, 2026

Isolation Method for Long-Term and Short-Term Hematopoietic Stem Cells
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Published on: May 19, 2023

Hematopoietic stem cell transplantation nursing: a practice variation study.

Margaret Bevans1, D Kathryn Tierney, Coleen Bruch

  • 1Clinical Center, National Institutes of Health, Bethesda, MD, USA. mbevans@cc.nih.gov

Oncology Nursing Forum
|November 6, 2009
PubMed
Summary

Hematopoietic stem cell transplantation (HSCT) nursing shows practice variation, particularly in patient hygiene and social restrictions post-transplant. Identifying these gaps is key to standardizing care and improving patient outcomes.

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Area of Science:

  • Oncology Nursing
  • Hematopoietic Stem Cell Transplantation (HSCT)

Background:

  • Hematopoietic stem cell transplantation (HSCT) nursing involves complex care with established standards.
  • Significant practice variation may exist across different healthcare settings.

Purpose of the Study:

  • To examine practice variations in HSCT nursing.
  • To identify the gap between recommended HSCT nursing standards and actual practice.
  • To explore additional practices relevant to HSCT nursing.

Main Methods:

  • A cross-sectional, descriptive survey was conducted.
  • Data were collected from 205 participants via electronic questionnaires.
  • The study focused on infection control practices in bone marrow transplantation settings.

Main Results:

  • Minimal variation was found in infection control practices across transplantation types.
  • Practices regarding patient hygiene, diet, and social interactions varied by transplantation phase, especially post-transplant.
  • Published guidelines were used by 62% of respondents, and organization-specific policies by 72%.

Conclusions:

  • Practice variation exists in HSCT nursing despite published standards.
  • The reasons for variation, whether non-compliance or unclear guidelines, require further investigation.
  • Identifying these inconsistencies is crucial for developing evidence-based projects to standardize HSCT practice and improve patient outcomes.