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Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...

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Related Experiment Video

Updated: Jun 19, 2026

Enrichment and Characterization of the Tumor Immune and Non-immune Microenvironments in Established Subcutaneous Murine Tumors
08:32

Enrichment and Characterization of the Tumor Immune and Non-immune Microenvironments in Established Subcutaneous Murine Tumors

Published on: June 7, 2018

Microenvironmental independence associated with tumor progression.

Alexander R A Anderson1, Mohamed Hassanein, Kevin M Branch

  • 1Integrated Mathematical Oncology, Moffitt Cancer Center, Tampa, Florida FL 33629, USA. alexander.anderson@moffitt.org

Cancer Research
|November 6, 2009
PubMed
Summary
This summary is machine-generated.

Tumor cells compete differently based on their environment. Transformed cells thrive in rich conditions, while aggressive tumorigenic cells excel in limited microenvironments, showing adaptability.

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Assessing Tumor Microenvironment of Metastasis Doorway-Mediated Vascular Permeability Associated with Cancer Cell Dissemination using Intravital Imaging and Fixed Tissue Analysis
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Area of Science:

  • * Mathematical modeling of biological systems
  • * Cancer cell biology and tumor microenvironment interactions
  • * Evolutionary game theory in cellular dynamics

Background:

  • * Tumor progression is significantly influenced by interactions within the tumor microenvironment.
  • * Understanding competitive cellular dynamics is crucial for comprehending tumor heterogeneity and progression.
  • * Phenotypic traits of normal, transformed, and tumorigenic cells vary, impacting their behavior in different environments.

Purpose of the Study:

  • * To investigate the competitive dynamics of various mammary cell phenotypes within diverse microenvironments.
  • * To mathematically model and simulate tumor cell competition under varying resource availability.
  • * To determine how microenvironmental constraints affect the selective advantage of different cell types.

Main Methods:

  • * Parameterization of a hybrid discrete-continuum mathematical model using phenotypic trait data from mammary cell lines.
  • * Simulation of heterogeneous tumor growth in both resource-rich and resource-constrained microenvironments.
  • * Application of game theory to analyze the relationship between microenvironment resource availability and cellular competitive strategies.

Main Results:

  • * In resource-rich environments, transformed (non-tumorigenic) cells outcompeted normal and tumorigenic cells.
  • * In constrained microenvironments, phenotypes derived from tumorigenic cell lines showed a selective advantage.
  • * Aggressive cell phenotypes were least affected by microenvironmental limitations, indicating a degree of microenvironmental independence.

Conclusions:

  • * Microenvironmental conditions dictate the competitive success of different tumor cell phenotypes.
  • * Microenvironmental independence is a key advantageous trait for cellular competitiveness in resource-limited settings.
  • * Mathematical modeling provides insights into the complex interplay between cell phenotype and tumor microenvironment.