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Prognostic factors of treatment outcomes in patients with granulocytic sarcoma
Tsung-Yu Lan1, Dong-Tsamn Lin, Hwei-Fang Tien
1Department of Orthopedics, National Taiwan University and Hospital, Taipei, Taiwan, ROC.
Purpose:
To investigate the possible prognostic factors of survival outcomes in patients with granulocytic sarcoma (GS).
Methods:
We retrospectively investigated the prognostic factors determining survival in 24 patients with GS using Kaplan-Meier survival analysis followed by log rank tests. We evaluated gender, age, location, GS antedating leukemia, underlying disorders, treatment type and stem cell transplantation.
Results:
The 5-year survival rate for the patients with GS was 21%. The patients undergoing chemotherapy had a significantly longer survival time compared to those who did not (p = 0.0009). We found no difference in the 5-year survival rate among the patients undergoing chemotherapy combined with radiation or surgery. Patients with chronic myelogenous leukemia and myelodysplastic disorders had worse survival rates (p = 0.0028).
Conclusion:
Early diagnosis with biopsy and early chemotherapy can improve survival outcome. Local radiation or surgery can improve symptoms but does not influence survival outcomes.
