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Related Concept Videos

Functions of Life01:23

Functions of Life

Human life is characterized by a variety of functions that are essential for survival and well-being. These functions include metabolism, movement, development, growth and reproduction.
Metabolism
The basic function of an organism is to consume energy and molecules in foods, convert some of it into fuel for movement, sustain body functions, and build and maintain body structures. There are two types of reactions that accomplish this: anabolism and catabolism.
Anabolism is the process whereby...
The DNA Helix01:07

The DNA Helix

Deoxyribonucleic acid, or DNA, is the genetic material responsible for passing traits from generation to generation in all organisms and most viruses. DNA is composed of two strands of nucleotides that wind around each other to form a spring-like structure called a double helix. However, the double helix is not perfectly symmetrical. Instead, there are regularly occurring grooves in the structure. The major groove occurs where the sugar-phosphate backbones are relatively far apart. This space...
The DNA Helix01:16

The DNA Helix

Overview
The DNA Helix01:16

The DNA Helix

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Life Histories01:29

Life Histories

Constrained by limited energy and resources, organisms must compromise between offspring quantity and parental investment. This trade-off is represented by two primary reproductive strategies; K-strategists produce few offspring but provide substantial parental support, whereas r-strategists produce much progeny that receives little care. These strategies are related to an organism’s survival likelihood across its lifespan, which is represented by a survivorship curve. Three general types of...
Entropy within the Cell01:22

Entropy within the Cell

A living cell's primary tasks of obtaining, transforming, and using energy to do work may seem simple. However, the second law of thermodynamics explains why these tasks are harder than they appear. None of the energy transfers in the universe are completely efficient. In every energy transfer, some amount of energy is lost in a form that is unusable. In most cases, this form is heat energy. Thermodynamically, heat energy is defined as the energy transferred from one system to another that is...

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Related Experiment Video

Updated: Jun 19, 2026

Focus Formation: A Cell-based Assay to Determine the Oncogenic Potential of a Gene
08:18

Focus Formation: A Cell-based Assay to Determine the Oncogenic Potential of a Gene

Published on: December 31, 2014

Myc's secret life without Max.

Peter Gallant1, Dominik Steiger

  • 1Universität Zürich, Zoologisches Institut, Zürich, Switzerland. gallant@zool.uzh.ch

Cell Cycle (Georgetown, Tex.)
|November 6, 2009
PubMed
Summary

Myc oncoproteins have essential roles, but recent findings show they retain activity independently of Max. This Max-independent function includes activating RNA polymerase III transcription, impacting cancer biology and drug development.

Area of Science:

  • Molecular biology
  • Oncology
  • Gene regulation

Background:

  • Myc transcription factors are potent human oncoproteins crucial for normal development.
  • It was widely believed that Myc's functions solely depend on heterodimerization with Max.
  • Emerging evidence suggests Myc possesses biological activity independent of Max binding.

Purpose of the Study:

  • To investigate the Max-independent activities of Myc.
  • To determine if Myc's role in RNA polymerase III transcription requires Max.
  • To explore the implications of Max-independent Myc functions on cancer biology and therapeutic strategies.

Main Methods:

  • The study likely involved molecular biology techniques to assess Myc activity in the presence and absence of Max.
  • Analysis of RNA polymerase III-dependent transcription was performed under varying Myc-Max binding conditions.

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A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae
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A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae

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Related Experiment Videos

Last Updated: Jun 19, 2026

Focus Formation: A Cell-based Assay to Determine the Oncogenic Potential of a Gene
08:18

Focus Formation: A Cell-based Assay to Determine the Oncogenic Potential of a Gene

Published on: December 31, 2014

The Replica Set Method: A High-throughput Approach to Quantitatively Measure Caenorhabditis elegans Lifespan
11:58

The Replica Set Method: A High-throughput Approach to Quantitatively Measure Caenorhabditis elegans Lifespan

Published on: June 29, 2018

A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae
10:39

A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae

Published on: September 17, 2020

Main Results:

  • Myc proteins demonstrate significant biological activity even when not bound to Max.
  • Myc's ability to activate RNA polymerase III-dependent transcription does not require association with Max.

Conclusions:

  • The discovery of Max-independent Myc functions challenges established models of Myc biology.
  • These findings suggest that targeting Myc's Max-independent activities could be a novel therapeutic approach in oncology.