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The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

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Directed therapy for exfoliation syndrome.

Allison Angelilli¹, Robert Ritch

¹Einhorn Clinical Research Center, New York Eye and Ear Infirmary, New York, NY, USA.

The Open Ophthalmology Journal

|November 6, 2009

Summary

Exfoliation syndrome (XFS) is an age-related matrix disorder causing glaucoma. New therapies targeting exfoliation material formation or depolymerization are needed for exfoliative glaucoma treatment.

Area of Science:

Ophthalmology
Extracellular Matrix Biology
Glaucoma Research

Background:

Exfoliation syndrome (XFS) is an age-related extracellular matrix disorder.
It leads to abnormal fibrillar material production, causing elevated intraocular pressure and severe glaucoma.
XFS is linked to ocular, cerebrovascular, neurodegenerative, and cardiovascular diseases.

Purpose of the Study:

To review current understanding of Exfoliation Syndrome (XFS).
To discuss current treatment modalities for XFS-related glaucoma.
To propose expanding the disease paradigm to include targeted therapies for the underlying disease process.

Main Methods:

Literature review of Exfoliation Syndrome (XFS) and its associations.
Analysis of current treatment strategies for exfoliative glaucoma.

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Identification of potential therapeutic targets for XFS.

Main Results:

Exfoliation material deposition occurs in ocular and extraocular tissues.
XFS is associated with systemic conditions like cerebrovascular and neurodegenerative diseases.
Current treatments focus on lowering intraocular pressure, but do not address the root cause.

Conclusions:

The disease paradigm for XFS requires expansion to include therapies targeting the underlying disease process.
Potential targets include preventing exfoliation material formation or promoting its depolymerization.
Novel therapies targeting the trabecular meshwork and neuroprotective agents are crucial for managing exfoliative glaucoma.