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NMR assignments of the human cytokine interleukin-33

Andreas Lingel1, Wayne J Fairbrother

  • 1Department of Protein Engineering, Genentech, South San Francisco, CA 94080, USA.

Biomolecular NMR Assignments
|November 6, 2009
PubMed

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The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
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