Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

C-reactive protein in normal pregnancy.

D H Watts1, M A Krohn, M H Wener

  • 1Department of Obstetrics and Gynecology, University of Washington, Seattle.

Obstetrics and Gynecology
|February 1, 1991
PubMed
Summary

Maternal serum C-reactive protein (CRP) levels are higher in normal pregnancy and further increase during labor. Understanding these baseline changes is crucial for accurately diagnosing infections in complicated pregnancies.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The complexity of an optimal vaginal biome.

BJOG : an international journal of obstetrics and gynaecology·2019
Same author

Obstetricians' awareness associated with better outcomes.

BJOG : an international journal of obstetrics and gynaecology·2017
Same author

Vaginal seeding: more questions than answers.

BJOG : an international journal of obstetrics and gynaecology·2017
Same author

Pharmacokinetics of tenofovir during pregnancy and postpartum.

HIV medicine·2015
Same author

Predictors of adverse pregnancy outcomes in women infected with HIV in Latin America and the Caribbean: a cohort study.

BJOG : an international journal of obstetrics and gynaecology·2014
Same author

Effects of individual and combined dietary weight loss and exercise interventions in postmenopausal women on adiponectin and leptin levels.

Journal of internal medicine·2013

Area of Science:

  • Obstetrics and Gynecology
  • Clinical Chemistry
  • Immunology

Background:

  • Maternal serum C-reactive protein (CRP) is a potential biomarker for subclinical infection in pregnancy.
  • Establishing baseline CRP levels in normal pregnancy and labor is essential before its use in complicated cases.

Purpose of the Study:

  • To determine the serial changes in maternal serum CRP levels throughout normal pregnancy and labor.
  • To establish reference ranges for CRP in healthy pregnant women.

Main Methods:

  • Serial measurement of maternal serum CRP from 22 weeks' gestation until delivery.
  • Inclusion of healthy pregnant women without antepartum complications.
  • Comparison of CRP levels in women not in labor versus women in labor at term.

Related Experiment Videos

Main Results:

  • Median CRP values in non-laboring pregnant women ranged from 0.7-0.9 mg/dL, with 95% below 1.5 mg/dL.
  • No consistent change in CRP with gestational age was observed in non-laboring women.
  • Median CRP in women in labor was 1.3 mg/dL, with 32% exceeding 1.5 mg/dL, indicating elevated levels during labor.

Conclusions:

  • Normal pregnancy is associated with higher CRP levels than nonpregnant individuals.
  • Labor further elevates maternal serum CRP levels.
  • Understanding these physiological changes is key for appropriate CRP interpretation in complicated pregnancies.