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Updated: Jun 19, 2026

Synthesis of Near-Infrared Emitting Gold Nanoclusters for Biological Applications
Published on: March 22, 2020
Antitumor activity of diethynylfluorene derivatives of gold(I)
Chung-Hin Chui1, Raymond Siu-Ming Wong, Roberto Gambari
1Institute of Textiles and Clothing, Hong Kong Polytechnic University, Hung Hom, Hong Kong, People's Republic of China.
Abstract:
A list of diethynylfluorenes and their gold(I) derivatives have been studied for their antitumor activity as a function of their structure-activity relationships. End-capping the fluoren-9-one unit with gold(I) moieties could significantly strengthen the cytotoxic activity in vitro on three human cancer cell lines with induction of reactive oxygen species generation on Hep3B hepatocellular carcinoma cells and exhibit attractive antitumor activity from in vivo nude mice Hep3B xenograft model with limited adverse effects on vital organs including liver and kidney.
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