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Revisiting the parietal cell.

Sascha Kopic1, Michael Murek, John P Geibel

  • 1Dept. of Surgery, Yale School of Medicine, BML 265, 310 Cedar St., New Haven, CT 06511. john.geibel@yale.edu.

American Journal of Physiology. Cell Physiology
|November 6, 2009
PubMed
Summary
This summary is machine-generated.

Parietal cells secrete gastric acid using specialized ion transport proteins. Recent research clarifies these mechanisms, updating models of parietal cell physiology and ion transport.

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Area of Science:

  • Gastroenterology
  • Cell Physiology
  • Molecular Biology

Background:

  • Parietal cells secrete concentrated hydrochloric acid (HCl) into the gastric lumen.
  • These cells utilize numerous functionally coupled apical and basolateral ion transport proteins for HCl secretion.
  • Previous research has identified the molecular basis of many of these transport mechanisms.

Purpose of the Study:

  • To review the current model of parietal cell physiology.
  • To specifically update the understanding of ion transport mechanisms in parietal cells.
  • To present the latest models of apical and basolateral transport.

Main Methods:

  • Literature review of recent scientific efforts.
  • Analysis of established models of parietal cell function.
  • Synthesis of new findings regarding ion transport proteins.

Main Results:

  • Significant progress has been made in identifying the molecular identity of parietal cell transport proteins.
  • The concerted efforts of researchers have clarified long-standing controversies in the field.
  • Updated models incorporate newly identified apical and basolateral transport mechanisms.

Conclusions:

  • The molecular understanding of parietal cell ion transport has advanced considerably.
  • Current models of parietal cell physiology and ion transport have been refined.
  • This review provides an updated perspective on apical and basolateral transport in parietal cells.