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Related Experiment Video

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Expression, Purification, and Antimicrobial Activity of S100A12

Expression, Purification, and Antimicrobial Activity of S100A12

Published on: May 13, 2017

S100A1: Structure, Function, and Therapeutic Potential.

Nathan T Wright¹, Brian R Cannon, Danna B Zimmer

¹Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, 108 N. Greene St., Baltimore, Maryland, 21201.

Current Chemical Biology

|November 6, 2009

Summary

This summary is machine-generated.

S100A1 is a calcium-binding protein with diverse targets. Inhibiting S100A1 shows therapeutic potential for diseases like cancer and heart failure with minimal side effects.

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Purification of Human S100A12 and Its Ion-induced Oligomers for Immune Cell Stimulation

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Published on: September 29, 2019

Area of Science:

Biochemistry
Molecular Biology
Cell Signaling

Background:

S100A1 is a calcium-binding protein central to cellular processes.
Upon calcium binding, S100A1 undergoes conformational changes to interact with various protein targets.
Its dual role as an intracellular and secreted protein complicates therapeutic development.

Purpose of the Study:

To explore the diverse protein interactions of S100A1.
To investigate the therapeutic potential of S100A1 inhibitors for various human diseases.
To address the complexities in developing S100A1-mediated therapies.

Main Methods:

Identification and characterization of S100A1 protein targets.
Analysis of S100A1's role in calcium signaling, neurotransmitter release, and cytoskeletal regulation.
Evaluation of S100A1 knockout mouse models for potential side effects of antagonists.

Main Results:

S100A1 interacts with a wide array of proteins involved in critical cellular functions.
Potential therapeutic applications for S100A1 inhibitors in neurological diseases, diabetes, heart failure, and cancer are suggested.
S100A1 knockout mice exhibit no significant phenotypic abnormalities, indicating potential safety for antagonists.

Conclusions:

S100A1 is a versatile protein with numerous targets, implicating it in various physiological and pathological processes.
S100A1 antagonists represent a promising therapeutic strategy with potentially minimal side effects.
Further research is required to fully elucidate S100A1-target interactions and their functional consequences for therapeutic development.