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Antiproliferative activity of Korean wild vegetables on different human tumor cell lines
Buk-Gu Heo1, Sang-Uk Chon, Yun-Jum Park
1Naju Foundation of Natural Dyeing Culture, Naju 520-931, South Korea.
Abstract:
This study was conducted to determine the antiproliferative activity of 24 Korean wild vegetables. The methanol extracts of these wild vegetables were used against lung, breast, colon and gastric cancer cells, and the results were assessed by MTT assay. It was found that at the extract concentration of 400 mgL(-1) 14 plants exercised antiproliferative activity over 80% against the lung cancer cells, one plant among six--against breast cancer cells, and two plants among six--against colon cancer cells, respectively. Eighteen wild vegetables had the hyperplasia inhibition activity against gastric cancer cells over 23.6% at all extract concentrations, however, only six plants had the antiproliferative activity over 80% in 600 mgL(-1). It was found that the extracts from Youngia sonchifolia, Synurus deltoides, Syneilesis palmata, and Cephalonoplos segetum, in concentration of 400 mgL(-1) inhibited the hyperplasia of lung cancer cells over 95% and Angelica gigas-both lung and colon cancer cells over 95%. In conclusion, the studied wild vegetables' methanol extracts possess dose dependent antiproliferative properties, based on their bioactive compounds, mainly polyphenols, but some of them as Hypericum ascyron against lung cancer are not effective and even course harm.
Insights
Korean wild vegetables show significant antiproliferative activity against various cancer cells. Extracts from Youngia sonchifolia, Synurus deltoides, Syneilesis palmata, Cephalonoplos segetum, and Angelica gigas demonstrated potent anti-cancer effects.
Area of Science:
- Botany
- Pharmacology
- Oncology
Background:
- Natural products are a vital source of anti-cancer compounds.
- Korean wild vegetables represent an underexplored resource for potential chemopreventive agents.
Purpose of the Study:
- To evaluate the antiproliferative effects of 24 Korean wild vegetables against human cancer cell lines.
- To identify specific wild vegetables with potent anti-cancer properties.
Main Methods:
- Methanol extracts of 24 wild vegetables were prepared.
- The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay was used to assess antiproliferative activity.
- Cancer cell lines included lung, breast, colon, and gastric cancer.
Main Results:
- 14 plants showed >80% antiproliferative activity against lung cancer cells at 400 mg/L.
- Angelica gigas demonstrated >95% inhibition against lung and colon cancer cells at 400 mg/L.
- Youngia sonchifolia, Synurus deltoides, Syneilesis palmata, and Cephalonoplos segetum also exhibited >95% inhibition against lung cancer cells.
Conclusions:
- Korean wild vegetables possess dose-dependent antiproliferative properties, attributed to bioactive compounds like polyphenols.
- Specific species show significant potential for development as anti-cancer agents.
- Further research is needed to isolate active compounds and confirm efficacy and safety.
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