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Related Concept Videos

Animal Mitochondrial Genetics02:59

Animal Mitochondrial Genetics

Among all the organelles in an animal cell, only mitochondria have their own independent genomes. Animal mitochondrial DNA is a double-stranded, closed-circular molecule with around 20,000 base pairs. Mitochondrial DNA is unique in that one of its two strands, the heavy, or H, -strand is guanine rich, whereas the complementary strand is cytosine rich and called the light, or L, -strand. Compared to nuclear DNA, mitochondrial DNA has a very low percentage of non-coding regions and is marked by...
Disorders of the Skeletal Muscle01:28

Disorders of the Skeletal Muscle

The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
Mitochondrial Precursor Proteins01:39

Mitochondrial Precursor Proteins

Mitochondrial precursors are partially unfolded or loosely folded polypeptide chains. Newly synthesized precursors are inhibited from spontaneously folding into their native conformation by the cytosolic chaperones, heat shock proteins 70 (Hsp70), and mitochondrial import stimulation factors (MSFs). Precursors bound to MSFs are guided to the TOM70-TOM37 receptors, while precursors bound to Hsp70  chaperones are targetted to TOM20-TOM22 receptor complexes.
Most of the mitochondrial precursors...
Mitochondrial Membranes01:45

Mitochondrial Membranes

A single mitochondrion is a bean-shaped organelle enclosed by a double-membrane system. The outer membrane of mitochondria is smooth and contains many porins - the integral membrane transporters. Porins enable free diffusion of ions and small uncharged molecules through the outer mitochondrial membrane but limit the transport of molecules larger than 5000 Daltons. Further, the outer mitochondrial membrane forms a unique structure called membrane contact sites with other subcellular organelles,...
Mitochondrial Membranes01:45

Mitochondrial Membranes

A single mitochondrion is a bean-shaped organelle enclosed by a double-membrane system. The outer membrane of mitochondria is smooth and contains many porins - the integral membrane transporters. Porins enable free diffusion of ions and small uncharged molecules through the outer mitochondrial membrane but limit the transport of molecules larger than 5000 Daltons. Further, the outer mitochondrial membrane forms a unique structure called membrane contact sites with other subcellular organelles,...
Cardiomyopathy I: Introduction and Classification01:25

Cardiomyopathy I: Introduction and Classification

Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...

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Updated: Jun 19, 2026

Visualization of Mitochondrial Respiratory Function using Cytochrome C Oxidase / Succinate Dehydrogenase (COX/SDH) Double-labeling Histochemistry
06:53

Visualization of Mitochondrial Respiratory Function using Cytochrome C Oxidase / Succinate Dehydrogenase (COX/SDH) Double-labeling Histochemistry

Published on: November 23, 2011

[Mitochondrial myopathies].

J Finsterer1

  • 1Krankenanstalt Rudolfstiftung, Wien/Osterreich. fifigs1@yahoo.de

Fortschritte Der Neurologie-Psychiatrie
|November 6, 2009
PubMed
Summary
This summary is machine-generated.

Mitochondrial myopathies affect skeletal muscles, causing fatigue and weakness. Diagnosis involves various tests, with treatment focusing on symptom management and supportive care.

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Area of Science:

  • Neurology
  • Genetics
  • Muscle Physiology

Context:

  • Mitochondrial disorders frequently impact skeletal muscle, leading to mitochondrial myopathies.
  • These myopathies can be isolated or part of broader syndromic conditions.
  • Skeletal muscle involvement ranges from subclinical to severe weakness and atrophy.

Purpose:

  • To outline the clinical presentation, diagnostic approaches, and therapeutic strategies for mitochondrial myopathies.
  • To highlight the diverse symptoms and progressive nature of these muscle disorders.
  • To emphasize the current limitations in treatment, focusing on symptomatic relief.

Summary:

  • Mitochondrial myopathies present with symptoms like fatigue, pain, cramps, and weakness, often progressing slowly.
  • Diagnosis requires a comprehensive approach including clinical evaluation, biochemical tests, imaging, and genetic analysis.
  • Management is symptomatic, involving physiotherapy, supportive devices, medication, and avoiding toxic agents, with careful consideration for anesthesia.

Impact:

  • Improved understanding of mitochondrial myopathy's clinical spectrum and diagnostic pathways.
  • Highlights the need for multidisciplinary care and symptomatic management strategies.
  • Informs clinical practice regarding patient care, including anesthetic considerations.