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Published on: September 9, 2020
Prognostic factors in pulmonary metastasized high-grade osteosarcoma
Emilie P Buddingh1, Jakob K Anninga, Michel I M Versteegh
1Department of Pediatric Hematology, Oncology and Bone Marrow Transplantation, Leiden University Medical Center, Leiden, The Netherlands.
Pediatric Blood & Cancer
|November 6, 2009
Summary
Surgical resection of pulmonary metastases can cure some osteosarcoma (OS) patients. Key factors for survival include resectability, relapse-free interval, male sex, number of nodules, and metastasis characteristics.
Area of Science:
- Oncology
- Surgical Oncology
- Pulmonary Metastases Research
Background:
- Pulmonary metastases are common in high-grade osteosarcoma (OS).
- Surgical resection of lung metastases can improve outcomes in OS patients.
- Identifying prognostic factors is crucial for clinical decision-making.
Purpose of the Study:
- To identify prognostic factors influencing survival in osteosarcoma patients with pulmonary metastases.
- To evaluate the impact of metastasectomy on survival outcomes.
Main Methods:
- Retrospective analysis of 88 osteosarcoma patients under 40 with pulmonary metastases (1990-2008).
- Data collected on patient demographics, tumor characteristics, treatment, and survival.
- Multivariate analysis to identify independent risk factors.
Main Results:
- Metastasectomy was performed in 56 of 88 patients; resectability was the main prognostic factor.
- Longer relapse-free interval to pulmonary metastases correlated with better survival (P=0.02).
- Independent risk factors for worse survival post-metastasectomy included male sex (P=0.05), higher nodule count (P=0.03), and non-necrotic metastases (P=0.04).
Conclusions:
- This study identified key risk factors for survival in osteosarcoma patients with pulmonary metastases.
- Repeated metastasectomies can lead to a cure in a subset of patients.
