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Updated: Jun 19, 2026

A Preclinical Murine Model of Hepatic Metastases
Published on: September 27, 2014
Pedunculated hepatocellular carcinoma and splenic metastasis
Mao-Lin Yan1, Yao-Dong Wang, Zhi-De Lai
1Department of Hepatobiliary Surgery, Fujian Provincial Hospital, Fuzhou 350001, Fujian Province, China.
Abstract:
Only a few cases of pedunculated hepatocellular carcinoma (P-HCC) have been reported in the literature. The common sites of extrahepatic metastases in patients with HCC are the lungs, regional lymph nodes, kidney, bone marrow and adrenals. Metastasis to spleen is mostly via hematogenous metastasis, direct metastasis to spleen was very rare. We report a case of P-HCC presenting as a left upper abdominal lesions which involved the spleen that was actually a P-HCC with splenic metastasis. This case is unique as P-HCC directly involved the spleen which is not via hematogenous metastasis.

