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Updated: Jun 19, 2026
Sub-acute Cerebral Microhemorrhages Induced by Lipopolysaccharide Injection in Rats
Published on: October 17, 2018
Protective effect of resveratrol against lipopolysaccharide-induced oxidative stress in rat brain
Hichem Sebai1, Wafa Gadacha, Mamane Sani
1Laboratoire de Biosurveillance de l'Environnement, Faculté des Sciences de Bizerte, Zarzouna, Tunisie.
Primary Objective:
To study the protective effect of resveratrol on endotoxemia-induced neurotoxicity.
Methods:
Rats were pre-treated during 7 days with 20 mg kg(-1) body weight (b.w.) resveratrol and challenged with a single dose of lipopolysaccharide (LPS: 8 mg kg(-1) b.w.) for 24 hours. Brains were harvested to determine LPS-induced lipoperoxidation level, antioxidant enzyme activities, nitric monoxide (NO) and iron distribution as well as the impact of resveratrol on these parameters.
Results:
Resveratrol counteracted LPS-induced brain malondialdehyde (MDA) level and antioxidant enzyme activities depletion as superoxide dismutase (SOD), catalase (CAT) and peroxidase (POD). Resveratrol also reversed LPS-induced brain and plasma NO elevation as well as iron sequestration from plasma to brain compartment.
Conclusion:
The data suggest that resveratrol is capable of alleviating LPS-induced neurotoxicity by a mechanism that may involve iron shuttling proteins.
