Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jun 19, 2026

Retinal Pathophysiological Evaluation in a Rat Model
09:11

Retinal Pathophysiological Evaluation in a Rat Model

Published on: May 6, 2022

Diabetic rat testes: morphological and functional alterations.

G Ricci1, A Catizone, R Esposito

  • 1Department of Experimental Medicine, Histology and Embryology Laboratory, School of Medicine, Second University of Naples and National Institute of Biostructures and Biosystems Interuniversitary Consortium-Unit of Sections of Naples, Naples, Italy. giulia.ricci@unina2.it

Andrologia
|November 7, 2009
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Zebrafish embryo extracts enhance 5-FU anti-cancer effects upon breast cancer cells.

European review for medical and pharmacological sciences·2021
Same author

Transient increases in intracellular calcium and reactive oxygen species levels in TCam-2 cells exposed to microgravity.

Scientific reports·2017
Same author

Stearoyl-CoA-desaturase 1 regulates lung cancer stemness via stabilization and nuclear localization of YAP/TAZ.

Oncogene·2017
Same author

Stearoyl-CoA-desaturase 1 regulates lung cancer stemness via stabilization and nuclear localization of YAP/TAZ.

Oncogene·2017
Same author

Responses of peripheral blood mononuclear cells to moderate exercise and hypoxia.

Scandinavian journal of medicine & science in sports·2015
Same author

Dystrophic tendon functionality is recovered by muscle-specific expression of insulin-like growth factor in mdx mice.

Journal of biomechanics·2012
Same journal

Correction.

Andrologia·2023
Same journal

The combination of ginger and zinc supplement could improve lead-induced reproductive dysfunction by inhibiting apoptosis mediated by oxidative damage and inflammation.

Andrologia·2022
Same journal

Testosterone and lifespan in males: At the right time and the right level.

Andrologia·2022
Same journal

CORRIGENDUM.

Andrologia·2022
Same journal

CORRIGENDUM.

Andrologia·2022
Same journal

Microfluidic devices employing chemo- and thermotaxis for sperm selection can improve sperm parameters and function in patients with high DNA fragmentation.

Andrologia·2022
See all related articles

Diabetes impairs male reproductive function. This study shows streptozotocin-induced diabetes in rats causes testicular damage, altered spermatogenesis, and reduced testosterone, with earlier onset leading to more severe effects, possibly via oxidative stress impacting Leydig cell function.

Area of Science:

  • Reproductive Endocrinology
  • Diabetic Complications
  • Histopathology

Background:

  • Diabetes mellitus is a known cause of reproductive dysfunction, but the specific mechanisms affecting testicular tissue remain unclear.
  • The impact of diabetes onset age on the severity of testicular damage is not well understood.
  • Oxidative stress is implicated in diabetic complications, potentially affecting male reproductive health.

Purpose of the Study:

  • To investigate the histological and molecular testicular alterations in rats with streptozotocin-induced diabetes.
  • To compare the severity of diabetes-induced testicular damage based on the age of disease onset (prepubertal vs. adult).
  • To explore the role of oxidative stress and testosterone levels in diabetic reproductive dysfunction.

Main Methods:

Related Experiment Videos

Last Updated: Jun 19, 2026

Retinal Pathophysiological Evaluation in a Rat Model
09:11

Retinal Pathophysiological Evaluation in a Rat Model

Published on: May 6, 2022

  • Induction of diabetes using streptozotocin in prepubertal (SPI) and adult (SAI) male rats.
  • Histological examination of testicular tissue to assess tubular damage and cytoarchitecture.
  • Evaluation of Leydig cell morphology, occludin distribution, and plasma testosterone levels.
  • Measurement of manganese superoxide dismutase as an indicator of oxidative stress.

Main Results:

  • Diabetic rats (SPI and SAI) exhibited abnormal testicular histology, including altered seminiferous epithelium and occludin distribution.
  • Earlier onset of diabetes (SPI) correlated with a higher percentage of damaged tubules.
  • Hypertrophy of the testicular interstitial compartment and abnormal Leydig cell distribution were observed in both SPI and SAI rats.
  • Plasma testosterone levels were similarly decreased in both SPI and SAI rats, and manganese superoxide dismutase was reduced.

Conclusions:

  • Streptozotocin-induced diabetes causes significant testicular damage and altered spermatogenesis, with earlier onset resulting in more severe effects.
  • Oxidative stress likely contributes to Leydig cell dysfunction, leading to decreased testosterone levels and subsequent damage to the seminiferous epithelium.
  • These findings highlight the detrimental impact of diabetes on male reproductive health, emphasizing the role of age at onset and oxidative stress.