Related Experiment Video
Updated: Jun 19, 2026
04:23
A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease
Published on: April 28, 2019
Dengue virus serotype 4, northeastern Peru, 2008
Brett M Forshey1, Amy C Morrison, Cristhopher Cruz
1US Naval Medical Research Center Detachment, Lima and Iquitos, Peru.
Emerging Infectious Diseases
|November 7, 2009
Summary
Dengue virus serotype 4 (DENV-4) emerged in Peru in 2008, causing a major outbreak. This new DENV-4 strain belonged to genotype II and was distinct from previously circulating dengue virus strains.
Area of Science:
- * Virology
- * Epidemiology
- * Genetics
Background:
- * Dengue virus serotype 3 (DENV-3) was endemic in northeastern Peru for six years prior to 2008.
- * Dengue virus is a significant public health concern in tropical and subtropical regions worldwide.
Purpose of the Study:
- * To investigate the emergence and phylogenetic characteristics of dengue virus serotype 4 (DENV-4) in northeastern Peru.
- * To understand the genetic relationship of the emergent DENV-4 strain to previously circulating strains.
Main Methods:
- * Phylogenetic analysis of viral isolates.
- * Genomic sequencing of dengue virus strains.
Main Results:
- * DENV-4 emerged in northeastern Peru in 2008, leading to a large outbreak.
- * The emergent DENV-4 displaced the predominant DENV-3 strain.
- * Phylogenetic analysis placed the 2008-2009 DENV-4 isolates into genotype II, forming a distinct lineage.
Conclusions:
- * A novel DENV-4 genotype II lineage emerged in Peru in 2008.
- * This emergence led to a significant shift in circulating dengue virus serotypes in the region.
Related Concept Videos
01:18Yellow Fever
Yellow fever is a viral hemorrhagic disease caused by the yellow fever virus (YFV), a member of the Flaviviridae family. It is transmitted primarily by Aedes and Haemagogus mosquitoes in tropical and subtropical regions of Africa and South America. After transmission through a mosquito bite, the virus initially replicates in skin-resident immune cells such as dendritic cells and macrophages. These cells then migrate to the lymph nodes, where viral replication increases, eventually leading to...
01:25Arboviral Encephalitis
Arboviral encephalitis refers to brain inflammation caused by arthropod-borne viruses, particularly those transmitted through mosquito vectors. Among these, West Nile virus (WNV), a member of the Flaviviridae family, is a significant public health concern. WNV is an enveloped, positive-sense, single-stranded RNA virus. Human infection typically begins when an infected mosquito introduces the virus into the dermis during feeding. The primary transmission cycle involves birds as amplifying hosts...
01:26Rocky Mountain Spotted Fever
Rocky Mountain Spotted Fever (RMSF) is a severe tick-borne illness caused by Rickettsia rickettsii, a Gram-negative, coccobacillary bacterium. This pathogen is an obligate intracellular parasite, requiring a host cell for replication. Transmission occurs through the bite of an infected tick. In the United States, the most important vectors are Dermacentor variabilis (American dog tick) and Dermacentor andersoni (Rocky Mountain wood tick), though other tick species may also serve as vectors.
01:22American Trypanosomiasis
Chagas disease, or American trypanosomiasis, is a vector-borne parasitic infection caused by Trypanosoma cruzi, a flagellated protozoan (kinetoplastid) of the family Trypanosomatidae. The disease is endemic in Latin America, although cases are increasingly reported worldwide due to human migration. Transmission most commonly occurs when feces of infected triatomine bugs contaminate bite wounds or mucosal surfaces; additional routes include congenital, transfusional, transplant-related, and oral...
01:29Malaria
Malaria pathogenesis in humans reflects a delicate interplay between parasite biology and host response. Clinical illness reflects a host’s immune response to the parasite’s asexual replication cycle, which is often asymptomatic in individuals with partial immunity. From the parasite's perspective, transmission between mosquito and human with minimal host pathology is evolutionarily advantageous. Among the six Plasmodium species infecting humans, P. falciparum and P. vivax dominate in global...
01:30Leishmaniasis
Leishmaniasis is a protozoal disease caused by species of the genus Leishmania and transmitted through the bite of infected female sandflies. The parasite exists in two principal morphological forms during its life cycle. A sandfly acquires intracellular amastigotes from an infected reservoir host, such as a dog. Within the sandfly, these forms differentiate into motile, flagellated promastigotes. During a subsequent blood meal, promastigotes are injected into the human host, where they...