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Related Experiment Video

Updated: Jun 19, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

Eosinophilic fasciitis/generalized morphea overlap.

Noushin Heidary¹, Wang Cheung, Nadia Wang

¹Department of Dermatology, New York University, USA.

Dermatology Online Journal

|November 7, 2009

Summary

This case study highlights a rare instance of inflammatory morphea progressing to eosinophilic fasciitis, even without typical eosinophilia. Treatment with methotrexate, glucocorticoids, and etanercept improved skin lesions and mobility.

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Last Updated: Jun 19, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

Area of Science:

Dermatology
Rheumatology
Internal Medicine

Background:

Inflammatory morphea and eosinophilic fasciitis are distinct connective tissue diseases.
Co-occurrence or progression between these conditions is rarely documented.
Understanding diagnostic criteria and treatment for overlapping presentations is crucial.

Observation:

A 50-year-old woman presented with violaceous, indurated plaques consistent with inflammatory morphea.
Over one year, she developed symptoms suggestive of eosinophilic fasciitis, including the groove sign.
Peripheral and histopathologic eosinophilia were absent.

Findings:

The patient was diagnosed with eosinophilic fasciitis despite the lack of eosinophilia, as it's not a mandatory diagnostic criterion.
A combination therapy of methotrexate, oral glucocorticoids, and etanercept was initiated.
Significant improvement in skin lesions and patient mobility was observed.

Implications:

This case expands the understanding of the potential progression from inflammatory morphea to eosinophilic fasciitis.
It underscores that eosinophilic fasciitis can be diagnosed without peripheral eosinophilia.
The successful treatment regimen suggests a potential therapeutic approach for similar complex cases.