Related Experiment Video
Updated: Jun 19, 2026

Targeting Alpha Synuclein Aggregates in Cutaneous Peripheral Nerve Fibers by Free-floating Immunofluorescence Assay
Published on: June 25, 2019
POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes)
Christine Liang1, Mercedes Gonzalez, Rishi Patel
1Department of Dermatology, New York University, USA.
Abstract:
A 62-year-old woman with hypothyroidism presented with a seven-year history of paresthesias, itching, and edema of the skin. Physical examination showed indurated, edematous plaques on the lower extremities. A biopsy specimen showed increased mucin deposition that was consistent with myxedema, and monoclonal IgM was observed on immunofixation. The constellation of findings, which included paresthesias, endocrinopathy, monoclonal gammopathy, and skin changes was consistent with POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes) syndrome, which is a rare multisystemic disease that is associated with an underlying plasma-cell dyscrasia.
Related Concept Videos
Nephrotic Syndrome I : Introduction
Chronic Kidney Disease II: Clinical Manifestations
Type I Diabetes III: Clinical Manifestations
Alterations in Muscle Tone lll
Pleiotropy
Graves' Disease I: Introduction
