Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Allergic Drug Reactions01:27

Allergic Drug Reactions

Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing numerous...
Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...
Drug toxicity: Idiosyncratic Reactions01:16

Drug toxicity: Idiosyncratic Reactions

Idiosyncratic drug reactions represent abnormal chemical responses that vary significantly among individuals, ranging from extreme sensitivity to low doses to insensitivity to high doses. These reactions often occur due to the drug's covalent binding with serum proteins, forming a foreign hapten that triggers an immunotoxicological response. The variability in drug reactions has a strong pharmacogenetic foundation, with genetic differences crucial in how individuals metabolize drugs. For...
Hypersensitivity Reactions: Cytolytic Reactions01:01

Hypersensitivity Reactions: Cytolytic Reactions

Type II hypersensitivity involves IgG and IgM antibodies targeting cell surface antigens, leading to cell destruction. This can occur through complement activation, antibody-dependent cell-mediated cytotoxicity (ADCC), or acting as opsonins for phagocytosis. When excessive, these reactions cause significant tissue damage.Drug-induced hemolytic anemia is a common example, where drugs like penicillin or cephalosporins bind to red blood cells, forming drug-protein complexes. These complexes...
Hypersensitivity Reactions: Immune-Complex Reactions01:19

Hypersensitivity Reactions: Immune-Complex Reactions

Type III hypersensitivity reactions occur when antigen–antibody complexes form and activate the complement system. Normally, these complexes help the clearance of antigens by phagocytes and red blood cells. However, when large numbers of immune complexes are present, they can deposit in tissues—particularly in the walls of blood vessels—leading to inflammation and tissue injury. These deposits trigger complement activation and neutrophil recruitment, resulting in serum sickness, a systemic...
Allergic Reactions02:06

Allergic Reactions

Overview

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Recombinant Antibody Against Human DRP1 Serine 616 Phosphorylation Enables Detection of BRAF<sup>V600E</sup>-Associated Mitochondrial Division in Cancer.

Antibodies (Basel, Switzerland)·2026
Same author

Relative survival analysis of dermatofibrosarcoma protuberans, Kaposi sarcoma, and pleomorphic sarcoma across intersectional demographics: A Surveillance, Epidemiology, and End Results (SEER) study.

Journal of the American Academy of Dermatology·2026
Same author

A Recombinant Antibody Against Human DRP1 Serine 616 Phosphorylation Enables Detection of BRAF <sup>V600E</sup> -Associated Mitochondrial Division in Cancer.

bioRxiv : the preprint server for biology·2026
Same author

Relative survival analysis of Merkel cell carcinoma across intersectional demographics using the Surveillance, Epidemiology, and End Results (SEER) database.

JAAD international·2025
Same author

SpotCheck: A skin cancer diagnostic accuracy study comparing teledermoscopy with and without electrical impedance spectroscopy to in-person dermatologist evaluation of patient-identified lesions concerning them for skin cancer.

Journal of the American Academy of Dermatology·2024
Same author

Cutaneous Diseases of Penoscrotal Skin-Part II: Infectious and Inflammatory Dermatoses.

Journal of the American Academy of Dermatology·2024
Same journal

Pellagra associated with iron deficiency.

Dermatology online journal·2026
Same journal

Demodicosis: A frequently underrecognized cause of recalcitrant ear pruritus.

Dermatology online journal·2026
Same journal

Association of alopecia areata with COVID-19 vaccination: A vaccine adverse events reporting system analysis.

Dermatology online journal·2026
Same journal

Gender based price differences in 5% minoxidil foam: The impact of generic alternatives and bulk packaging.

Dermatology online journal·2026
Same journal

Retrospective analysis of filler complications reported in the manufacturer and user facility device experience database from 2015 to 2025.

Dermatology online journal·2026
Same journal

Characterizing barriers to care in patients with hidradenitis suppurativa.

Dermatology online journal·2026
See all related articles

Related Experiment Video

Updated: Jun 19, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering
12:23

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

Lichenoid drug eruption.

Jeremy Brauer1, Henry J Votava, Shane Meehan

  • 1Department of Dermatology, New York University, USA.

Dermatology Online Journal
|November 7, 2009
PubMed
Summary
This summary is machine-generated.

A rare case of lichenoid drug eruption, a skin condition, was linked to proton-pump inhibitors. This adverse reaction highlights the importance of considering medication side effects in dermatology.

Related Experiment Videos

Last Updated: Jun 19, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering
12:23

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

Area of Science:

  • Dermatology
  • Pharmacology

Background:

  • Lichenoid drug eruptions are hypersensitivity reactions to medications.
  • Proton-pump inhibitors (PPIs) are commonly prescribed for acid-related gastrointestinal disorders.

Observation:

  • A 78-year-old male presented with a widespread, eight-month history of pink, hyperkeratotic papules and plaques with thick white scale.
  • The eruption predominantly affected the trunk, buttocks, and genitalia.
  • Dermatopathological examination revealed a superficial, band-like lymphocytic infiltrate with vacuolar changes at the dermo-epidermal junction.

Findings:

  • The patient was diagnosed with a lichenoid drug eruption.
  • The eruption was attributed to the use of a proton-pump inhibitor.
  • This represents the third reported case globally of a lichenoid drug eruption associated with PPIs.

Implications:

  • Clinicians should consider PPIs as a potential cause of lichenoid drug eruptions.
  • Early recognition and withdrawal of the offending agent are crucial for management.
  • Further research is warranted to understand the mechanisms and incidence of PPI-induced cutaneous reactions.