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Tissue Transplantation

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...

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Updated: Jun 19, 2026

A Human Cerebral Organoid Model of Neural Cell Transplantation

A Human Cerebral Organoid Model of Neural Cell Transplantation

Published on: July 21, 2023

Chapter 55: neural transplantation.

Stephen B Dunnett¹

¹School of Biosciences, Cardiff University, Cardiff, Wales, UK. dunnettSB@cf.ac.uk

Handbook of Clinical Neurology

|November 7, 2009

Summary

This summary is machine-generated.

Cell transplantation in the nervous system has evolved from early experimental attempts to a powerful neuroscience tool. Modern techniques now enable cell therapies for nervous system repair and disease treatment.

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Area of Science:

Neuroscience
Cell Biology
Medical History

Background:

The history of cell transplantation in the nervous system spans over a century, evolving through distinct eras.
Early attempts (1890-1940) faced challenges with cell viability and implantation success.
The middle era (1940-1970) established techniques for embryonic tissue transplantation in specific systems, though results were often disregarded due to prevailing views on brain immutability.

Observation:

The modern era (post-1970) utilized advanced anatomical techniques to demonstrate the regenerative capacity of transplanted cells.
Significant progress has been made in developing reliable transplantation technologies and analytical methods.
Cell transplantation is now a key method for analyzing nervous system function and development.

Findings:

Modern cell transplantation techniques reveal the nervous system's plasticity and repair potential.
These methods are crucial for understanding neuronal development, regeneration, and plasticity.
Cell transplantation is increasingly used to study and develop therapies for central nervous system injuries and diseases.

Implications:

Cell transplantation has become an indispensable tool in neuroscience research.
It offers powerful insights into neural development, regeneration, and plasticity.
Translational research is advancing cell transplantation therapies for neurological disorders like Parkinson's disease.