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Related Concept Videos

Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...

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Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions
07:30

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions

Published on: April 23, 2021

Cerebral white matter hyperintensities predict functional stroke outcome.

Li-Min Liou1, Chien-Fu Chen, Yuh-Cherng Guo

  • 1Department of Neurology, Kaohsiung Municipal Hsiaokang Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC.

Cerebrovascular Diseases (Basel, Switzerland)
|November 7, 2009
PubMed
Summary
This summary is machine-generated.

White matter hyperintensities (WMHs) impact stroke outcomes. Periventricular WMHs significantly predict poor functional recovery, while subcortical WMHs show a weaker association.

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A Versatile Murine Model of Subcortical White Matter Stroke for the Study of Axonal Degeneration and White Matter Neurobiology
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Published on: March 17, 2016

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Last Updated: Jun 18, 2026

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions
07:30

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A Versatile Murine Model of Subcortical White Matter Stroke for the Study of Axonal Degeneration and White Matter Neurobiology
08:36

A Versatile Murine Model of Subcortical White Matter Stroke for the Study of Axonal Degeneration and White Matter Neurobiology

Published on: March 17, 2016

Area of Science:

  • Neurology
  • Radiology
  • Stroke Medicine

Background:

  • White matter hyperintensities (WMHs) are increasingly linked to stroke recurrence and mortality.
  • The specific location of WMHs, whether periventricular (PVWMHs) or subcortical (SWMHs), may critically influence patient outcomes.

Purpose of the Study:

  • To investigate the differential impact of PVWMHs and SWMHs on functional outcomes in patients following acute ischemic stroke.

Main Methods:

  • 187 acute ischemic stroke patients underwent brain MRI.
  • WMHs were identified using a Fazekas score ≥2.
  • Functional outcomes were assessed at 30 days using the Barthel Index (BI) and modified Rankin Scale (mRS).

Main Results:

  • WMHs showed an inverse correlation with favorable functional outcomes (mRS and BI).
  • PVWMHs were significantly associated with unfavorable outcomes (p=0.002 for mRS, p=0.001 for BI).
  • SWMHs correlated with mRS (p=0.026) but not BI (p=0.069). After adjustments, PVWMHs remained a significant predictor of poor outcomes.

Conclusions:

  • MRI-detected WMHs are associated with unfavorable functional outcomes post-stroke.
  • Periventricular WMHs, specifically, are a significant predictor of poorer functional outcomes, unlike subcortical WMHs.