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[Macrovascular diabetic complications: clinical characteristics, diagnosis and management]
Cristina Triches1, Beatriz D'Agord Schaan, Jorge Luiz Gross
1Programa de Pós-graduação em Ciências Médicas: Endocrinologia e Metabologia, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brasil.
Insights
Diabetes mellitus (DM) significantly increases cardiovascular disease risk and mortality. Intensive treatment and strict risk factor control are crucial for improving outcomes in patients with diabetic macrovascular complications.
Area of Science:
- Cardiology
- Endocrinology
- Public Health
Context:
- Diabetes mellitus (DM) is a major independent risk factor for cardiovascular diseases (CVDs), including coronary heart disease, stroke, peripheral arterial disease, and heart failure.
- Patients with DM and established CVD exhibit poorer prognoses, lower survival rates, and increased recurrence risk compared to non-diabetic individuals.
- Despite advancements in diagnosis and therapy, the absolute mortality risk in diabetic patients with CVD remains double that of non-diabetic patients.
Purpose:
- To outline the key clinical characteristics of patients suffering from diabetic macrovascular disease.
- To present a practical approach for the screening, diagnosis, and management of diabetic macrovascular complications.
- To emphasize the importance of intensive treatment strategies for cardiovascular risk reduction in diabetic patients.
Summary:
- This study details the clinical profiles of individuals with diabetic macrovascular disease.
- It provides a guide for identifying, diagnosing, and treating these patients.
- The focus is on aggressive management of cardiovascular risk factors.
Impact:
- Highlights the critical need for proactive cardiovascular risk management in diabetes care.
- Aims to improve clinical decision-making for better patient outcomes.
- Underscores the persistent high mortality risk associated with diabetic macrovascular disease, necessitating optimized therapeutic interventions.
Abstract:
Diabetes mellitus (DM) is an independent risk factor for coronary heart disease, stroke, peripheral arterial disease and heart failure, which are the main causes of death in these patients. Moreover, patients with DM and cardiovascular disease have a worse prognosis than nondiabetics, present lower short-term survival, higher risk of recurrence of the disease and a worse response to the treatments proposed. In the last decades, diagnostic and therapeutic progress had already shown benefits concerning cardiovascular risk reduction in these patients, but their absolute mortality risk is still twice that of non-diabetic patients. Because of this, the adoption of intensive treatment, with strict cardiovascular risk factor control, is a priority. The present study presents the main clinical characteristics and also the practical approach for screening, diagnosis and treatment of patients with diabetic macrovascular disease.
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