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Updated: Jun 18, 2026
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Process Optimization using High Throughput Automated Micro-Bioreactors in Chinese Hamster Ovary Cell Cultivation
Published on: May 18, 2020
Microstructured reactors as tools for the intensification of pharmaceutical reactions and processes
Paul Chin1, William S Barney, Bradford A Pindzola
1TIAX LLC, 15 Acorn Park, Cambridge, MA 02140, USA.
Current Opinion in Drug Discovery & Development
|November 7, 2009
Summary
Process intensification using microstructured reactors enhances chemical processes by improving yield and purity. This review examines challenges and progress in adopting these advanced reactors for better organic reactions.
Area of Science:
- Chemical Engineering
- Process Chemistry
Background:
- Process intensification aims to reduce costs and energy consumption in chemical manufacturing.
- Microstructured reactors offer enhanced heat and mass transfer for precise reaction control.
Purpose of the Study:
- To review the role of microstructured reactors in process intensification.
- To highlight challenges and progress in adopting microstructured reactors for organic reactions.
Main Methods:
- Literature review of process intensification strategies.
- Analysis of microstructured reactor performance in organic synthesis.
Main Results:
- Microstructured reactors enable precise control over reaction time, temperature, and mixing.
- Improvements in selectivity and conversion for organic reactions have been observed.
- Challenges to widespread adoption remain, but progress is being made.
Conclusions:
- Microstructured reactors are key to implementing process intensification.
- Overcoming current challenges will facilitate broader adoption of these technologies for efficient chemical synthesis.
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