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Related Concept Videos

The Nucleolus02:55

The Nucleolus

The nucleolus is the most prominent substructure of the nucleus. When it was first discovered, it was considered to be an isolated organelle that forms fibrils and granules. In 1931, the relationship between the nucleolus and chromosomes was first described by Heitz. He observed that the appearance and size of nucleolus varies depending on the stage of the cell cycle. He also noticed constricted regions on different chromosomes clustered together at definite cell cycle stages. These regions,...
Cancers Originate from Somatic Mutations in a Single Cell02:21

Cancers Originate from Somatic Mutations in a Single Cell

Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
Cancers Originate from Somatic Mutations in a Single Cell02:21

Cancers Originate from Somatic Mutations in a Single Cell

Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
The Nucleus01:32

The Nucleus

The nucleus is a membrane-bound organelle that acts as a control center in a eukaryotic cell. It contains chromosomal DNA, which controls gene expression and precisely regulates the production of proteins within the cell. In contrast, the DNA inside the mitochondria and chloroplast only carries out functions that are specific to those organelles.
Arrangement of DNA within Nucleus
The regulation of gene expression inside the nucleus is dependent on many factors, including the DNA structure. The...
The Nucleus01:25

The Nucleus

The nucleus is a membrane-bound organelle that acts as a control center in a eukaryotic cell. It contains chromosomal DNA, which controls gene expression and precisely regulates the production of proteins within the cell. In contrast, the DNA inside the mitochondria and chloroplast only carries out functions that are specific to those organelles.
Arrangement of DNA within Nucleus
The regulation of gene expression inside the nucleus is dependent on many factors, including the DNA structure. The...
The Nucleus01:25

The Nucleus

The nucleus is a membrane-bound organelle that acts as a control center in a eukaryotic cell. It contains chromosomal DNA, which controls gene expression and precisely regulates the production of proteins within the cell. In contrast, the DNA inside the mitochondria and chloroplast only carries out functions that are specific to those organelles.
Arrangement of DNA within Nucleus
The regulation of gene expression inside the nucleus is dependent on many factors, including the DNA structure. The...

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Cancer nucleus: morphology and beyond.

Pranab Dey1

  • 1Department of Cytology, PGIMER, Chandigarh 160012, India. deypranab@hotmail.com

Diagnostic Cytopathology
|November 7, 2009
PubMed
Summary

Cancer cell nuclei show significant morphological changes detectable by light microscopy, impacting cellular functions. This review explores the relationship between nuclear structure, morphology, and cancer progression.

Area of Science:

  • Oncology
  • Cell Biology
  • Pathology

Background:

  • Cancer cells exhibit distinct nuclear morphological alterations visible under light microscopy.
  • These nuclear changes are often linked to abnormal cellular functions in malignant cells.
  • The precise connection between nuclear morphology and structural organization in cancer remains challenging to elucidate.

Purpose of the Study:

  • To review the significant visual and subvisual morphological changes in cancer cell nuclei.
  • To discuss the potential causes (etiology) and implications (significance) of these nuclear alterations.
  • To enhance understanding of nuclear structure-function relationships in cancer.

Main Methods:

  • Review of existing literature on cancer cell nuclear morphology.

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  • Analysis of light microscopy findings in routine cancer cell staining.
  • Correlation of morphological changes with known cellular dysfunctions.

    • Main Results:

    • Identified key visual and subvisual morphological alterations in cancer nuclei.
    • Discussed various etiological factors contributing to nuclear changes.
    • Highlighted the functional significance of observed morphological variations.

    Conclusions:

    • Nuclear morphology provides crucial insights into cancer cell biology.
    • Understanding these changes aids in cancer diagnosis and prognosis.
    • Further research is needed to fully unravel the nuclear structural organization in cancer.