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[Vascular diseases in first-degree relatives of patients with intracranial aneurysms]

E R Lebedeva, V P Sakovich

    Zhurnal Nevrologii I Psikhiatrii Imeni S.S. Korsakova
    |November 7, 2009
    PubMed

    Insights

    First-degree relatives of patients with intracranial aneurysms (IA) have significantly higher rates of vascular diseases, including stroke and heart disease. Genetic factors may predispose individuals to IA and other vascular conditions, necessitating preventative care.

    Area of Science:

    • Neurology
    • Cardiology
    • Genetics

    Background:

    • Intracranial aneurysms (IA) are a significant cause of cerebrovascular disease.
    • Understanding the familial aggregation of vascular diseases can elucidate underlying genetic predispositions.

    Purpose of the Study:

    • To compare the frequency of vascular diseases in first-degree relatives (FDR) of patients with IA versus FDR of controls.
    • To investigate potential genetic links between IA and other vascular conditions.

    Main Methods:

    • Case-control study involving 194 patients with IA and 193 matched controls.
    • Detailed interviews and pedigree analysis of 1011 FDR of IA patients and 812 FDR of controls.
    • Inclusion criteria required complete information on disorders within FDR.

    Main Results:

    • FDR of IA patients exhibited 2.5 times higher stroke frequency and 3.7 times higher hemorrhage frequency compared to controls.
    • Increased prevalence of headaches (2.8x), ischemic heart disease (2.7x), and arterial hypertension (2x) was observed in FDR of IA patients.
    • Sudden death occurred 5.8 times more frequently in FDR of IA patients; IA rupture was rare (0.9%) in this group.

    Conclusions:

    • Vascular defects leading to IA may have a partial genetic basis.
    • First-degree relatives of IA patients are at increased risk for various vascular diseases.
    • Preventative strategies for stroke and cardiovascular disease are recommended for FDR of IA patients.

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