Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jun 18, 2026

From a Natural Product to Its Biosynthetic Gene Cluster: A Demonstration Using Polyketomycin from Streptomyces diastatochromogenes Tü6028
09:08

From a Natural Product to Its Biosynthetic Gene Cluster: A Demonstration Using Polyketomycin from Streptomyces diastatochromogenes Tü6028

Published on: January 13, 2017

[Steroids from Monascus purpureus metabolite].

Xiaoya Shang1, Ruolan Wang, Suqin Yin

  • 1Beijing Key Laboratory of Bioactive Substances and Functional Foods, Beijing Union University, Beijing 100083, China. shangxiaoya@tgi.edu.cn

Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica
|November 10, 2009
PubMed
Summary

Researchers identified eight chemical compounds from Monascus purpureus, a fungus known for its medicinal properties. Six of these compounds were novel discoveries for this specific organism.

Related Concept Videos

Drug Metabolism: Phase II Reactions01:14

Drug Metabolism: Phase II Reactions

Phase II reactions are essential for the detoxification and elimination of drugs from the body. These reactions involve the conjugation of parent drugs or their phase I metabolites with endogenous molecules, resulting in more hydrophilic drug conjugates. The primary conjugation reactions in this phase are sulfation and glucuronidation. Both sulfation and glucuronidation typically produce biologically inactive metabolites. However, in some cases involving prodrugs, active metabolites may be...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Early radiotherapy delays acquired gefitinib resistance in EGFR-mutant NSCLC by suppressing c-FOS-associated survival signaling.

Respiratory research·2026
Same author

Sodium Butyrate Attenuates Sevoflurane-Induced Impaired Myelination and Neurobehavioral Deficits in Neonatal Mice via the H3K9ac/BDNF/TrkB Pathway.

CNS neuroscience & therapeutics·2026
Same author

Impact of prenatal maternal LDH levels on adverse pregnancy outcomes in women with hypertensive disorders during pregnancy.

Taiwanese journal of obstetrics & gynecology·2026
Same author

Identification of QTLs and genes regulating panicle number through genome-wide association studies in <i>Oryza sativa</i> L.

Frontiers in plant science·2026
Same author

Natural variation of <i>CTS1</i> confers cold tolerance and blast resistance in rice.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Case Report: Self-limiting penetrating cardiothoracic injury from a barbed shark dart involving the right atrium.

Frontiers in cardiovascular medicine·2026

Area of Science:

  • Natural Product Chemistry
  • Mycology
  • Organic Chemistry

Background:

  • Monascus purpureus is a fungus with a long history of use in traditional medicine.
  • Its metabolites are known to possess various bioactive properties.
  • Understanding the chemical composition is crucial for exploring its therapeutic potential.

Purpose of the Study:

  • To isolate and identify the chemical constituents present in the metabolites of Monascus purpureus.
  • To characterize novel compounds and expand the knowledge of fungal secondary metabolites.

Main Methods:

  • Extraction of Monascus purpureus metabolites using an ethanolic solvent.
  • Fractionation of the extract using petroleum ether.
  • Isolation of compounds via column chromatography.

Related Experiment Videos

Last Updated: Jun 18, 2026

From a Natural Product to Its Biosynthetic Gene Cluster: A Demonstration Using Polyketomycin from Streptomyces diastatochromogenes T&#252;6028
09:08

From a Natural Product to Its Biosynthetic Gene Cluster: A Demonstration Using Polyketomycin from Streptomyces diastatochromogenes Tü6028

Published on: January 13, 2017

  • Structure elucidation using spectroscopic techniques.

    • Main Results:

    • Eight compounds were successfully isolated from the petroleum ether fraction.
    • The identified compounds include stigmast-4-en-3-one, 3-oxo-24-methylenecycloarane, stigmasterol, 7beta-hydroxystigmasterol, 3beta-hydroxystigmast-5-en-7-one, 3beta-hydroxystigmast-5,22-dien-7-one, 5alpha, 8alpha-epidioxyergosta-6,22-dien-3beta-ol, and sitosterol.
    • Six of the eight isolated compounds were reported for the first time from this organism.

    Conclusions:

    • The study successfully identified eight chemical constituents from Monascus purpureus.
    • Six of these compounds represent new discoveries for this fungal species.
    • This research contributes to the understanding of Monascus purpureus's chemical diversity.