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Automated Compression Testing of the Ocular Lens

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Determination of corneal elasticity coefficient using the ORA database.

Sergei E Avetisov¹, Ivan A Novikov, Irina A Bubnova

¹Research Institute of Eye Diseases of the Russian Academy of Medical Sciences, Moscow, Russia.

Journal of Refractive Surgery (Thorofare, N.J. : 1995)

|November 10, 2009

Summary

A new elasticity coefficient (Ke) derived from Ocular Response Analyzer (ORA) data quantifies corneal biomechanics. This method effectively differentiates normal corneas from those with keratoconus, LASIK, or glaucoma, showing reduced Ke in disease states.

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Area of Science:

Ophthalmology
Biomedical Engineering
Corneal Biomechanics

Background:

Corneal biomechanics are crucial for understanding ocular health and disease.
Current methods for assessing corneal biomechanics have limitations.
The Ocular Response Analyzer (ORA) provides valuable data for corneal analysis.

Purpose of the Study:

To introduce a novel approach for studying corneal biomechanics.
To utilize the Ocular Response Analyzer (ORA) database for this new analysis.
To calculate an elasticity coefficient (Ke) based on velocity retardation at peak corneal flattening.

Main Methods:

Mathematical analysis of the ORA applanation curve.
Calculation of the elasticity coefficient (Ke) as a measure of corneal elastic properties.

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Comparison of Ke values across different patient groups: normal, keratoconus, LASIK, and glaucoma.

Main Results:

The mean Ke value in normal corneas was 11.05 ± 1.6.
Significantly lower mean Ke values were observed in keratoconus (4.91 ± 1.87), LASIK (5.99 ± 1.18), and glaucoma groups.
Glaucoma patients showed a reduction in Ke despite increased corneal hysteresis.

Conclusions:

The calculated elasticity coefficient (Ke) is a viable metric for evaluating corneal biomechanical properties.
This method offers a new way to assess corneal health and disease.
Ke values can help differentiate between various corneal conditions.